Elucidation of epithelial-stromal interactions in prostate cancer using global gene expression analysis
| Project/Area Number |
20790275
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORIKAWA Teppei The University of Tokyo, 医学部附属病院, 助教 (80451772)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 前立腺癌 / 間質 / ペリオスチン / 組織マイクロアレイ / 遺伝子発現解析 |
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| Research Abstract |
We focused on periostin, which was specifically expressed by prostate cancer stromal cells. We examined the expression of periostin protein in surgically resected prostate cancers by immunohistochemistry using a tissue microarray. We confirmed that periostin was exclusively expressed by prostate cancer stromal cells, but not by normal or cancerous epithelial cells. There was no significant association between periostin expression and clinicopathological features. Periostin expression in the stroma of prostate cancer may be a potential diagnostic marker.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma2009
Author(s)
Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K, Fukayama M
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Journal Title
Cancer Res 69(7)
Pages: 2766-74
Related Report
Peer Reviewed
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