| Project/Area Number |
20790276
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IWAI Miwako The University of Tokyo, 医科学研究所, 技術専門職員 (50396884)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子病理 / 小細胞肺癌 / 細胞接着分子 / TSLC1 / CADM1 / スプライシングバリアント / TSLC1/CADM1 / スプライシング・バリアント / TSLCl |
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| Research Abstract |
Small cell lung cancer (SCLC) accounts for about 20% of lung cancer in Japan. Although chemotherapy is initially effective to SCLC, SCLC often becomes resistant to any therapeutic approaches. Molecular targeting therapy, however, has not been established so far against SCLC. In this study, we found that a cell adhesion molecule, TSLC1/CADM1, was frequently overexpressed in cancer cells and primary tumors from SCLC, and showed a specific splicing isoform which was not observed in normal lung or brain. Furthermore, the exogenous expression of this variant TSLC1 promoted the tumorigenicity of SCLC cells in nude mice. These findings suggested that this splicing variant was associated with the malignant growth and metastasis of SCLC and could provide a useful marker for the diagnosis of SCLC.
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