Research of cellular senescence in hepatocarcinogenesis

• Project/Area Number: 20790277
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Kanazawa University
• Principal Investigator: IKEDA Hiroko Kanazawa University, 附属病院, 准教授 (10447675)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 癌 / 病理学 / 細胞老化 / 肝ステム細胞 / 肝細胞癌 / ステム細胞 / ディスプラジア / セネッセンス

Research Abstract

Cellular senescence is defined as the irreversible arrest of cell cycle. Senescence in premalignant lesion and escape from senescence are thought to be important the early stage of tumoriogenesis. Senescence-associated markers are observed in cirrhotic liver and the markers disappear in dysplastic nodules. The results imply that the cirrhotic state already might to be premalignancy.

Research Products

• [Journal Article] Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion (2009)
  • Author(s): Ikeda H, Sasaki M, Sato Y, Harada K, Zen Y, Mitsui T, Nakanuma Y
  • Journal Title: Hum Pathol 40 Pages: 1774-1782
  • Peer Reviewed
• [Journal Article] Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost in hepatocarcinogenesis (2009)
  • Author(s): Ikeda H, Sasaki M, Sato Y, Harada K, Zen Y, Mitsui T, Nakanuma Y
  • Journal Title: Pathol Int 59 Pages: 471-478
  • Peer Reviewed
• [Journal Article] Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion. (2009)
  • Author(s): Ikeda H.
  • Journal Title: Human Pathology 40 Pages: 1774-1782
  • Peer Reviewed
• [Journal Article] Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost during hepatocarcinogenesis. (2009)
  • Author(s): Ikeda H.
  • Journal Title: Pathology International 59 Pages: 471-478
  • NAID: 10027380731
  • Peer Reviewed
• [Presentation] Feature of the cellular senescence in large cell change of hepatocytes (liver cell dysplasia) in hepatitis B virus-related cirrhotic liver (2008)
  • Author(s): Ikeda H., et, al
  • Organizer: AASLD (American Association for the Stusy of Liver Disease)
  • Place of Presentation: Moscone West Convention Center(USA)
  • Year and Date: 2008-11-03
• [Presentation] Involvement of escape mechanism from cellular senescence associated with activated hepatic progenitor cells in hepatocarcinogenesis (2008)
  • Author(s): Ikeda H., et, al
  • Organizer: AASLD (American Association for the Stusy of Liver Disease)
  • Place of Presentation: Moscone West Convention Center(USA)
  • Year and Date: 2008-11-03
• [Presentation] Feature of the cellular senescence in large cell change of hepatocytes (liver cell dysplasia) in hepatitis B virus-related cirrhotic liver (2008)
  • Author(s): 池田博子
  • Organizer: AASLD (American Association for the Stusy of Liver Disease)
  • Place of Presentation: San Francisco
  • Year and Date: 2008-11-03
• [Presentation] Involvement of escape mechanism from cellular senescence associated with activated hepatic progenitor cells in hepatocarcinogenesis (2008)
  • Author(s): 池田博子
  • Organizer: AASLD (American Association for the Stusy of Liver Disease)
  • Place of Presentation: San Francisco
  • Year and Date: 2008-11-03
• [Presentation] 肝細胞癌発生過程におけるHepatic progenitor cellと細胞老化回避機構の関与 (2008)
  • Author(s): 池田博子, 他
  • Organizer: 第12回日本肝臓学会大会
  • Place of Presentation: グランドブリンスホテル新高輪(東京)
  • Year and Date: 2008-10-01
• [Presentation] 肝細胞癌発生過程におけるHepatic progenitor cellと細胞老化回避機構の関与 (2008)
  • Author(s): 池田博子
  • Organizer: JDDW日本消化器関連学会機構
  • Place of Presentation: 東京
  • Year and Date: 2008-10-01
• [Presentation] 肝細胞癌発生過程における細胞老化cellular senescenceの関与-肝ディスプラジア結節における細胞老化回避肝細胞の局在とstem cell featureについての検討- (2008)
  • Author(s): 池田博子, 他
  • Organizer: 第44回日本肝臓学会
  • Place of Presentation: 愛媛県県民文化会館(愛媛県)
  • Year and Date: 2008-06-05
• [Presentation] 肝細胞癌発生過程における細胞老化cellular senescenceの関与-肝ディスプラジア結節における細胞老化回避肝細胞の局在とstem cell featureについての検討- (2008)
  • Author(s): 池田博子
  • Organizer: 日本肝臓学会た
  • Place of Presentation: 愛媛
  • Year and Date: 2008-06-05