Analysis of sulfotransferases involved in biosynthesis of selectin ligand carbohydrates in ulcerative colitis
Project/Area Number |
20790278
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Human pathology
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Research Institution | Shinshu University |
Principal Investigator |
KOBAYASHI Motohiro Shinshu University, 医学系研究科, 講師 (00362137)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 潰瘍性大腸炎 / 翻訳後修飾 / 高内皮細静脈様血管 / MAdCAM-1 / セレクチンリガンド糖鎖 / L-セレクチンリガンド糖鎖 |
Research Abstract |
A diffuse lymphocyte infiltrate characterizes ulcerative colitis, and requires at least one of the two molecular interactions: one via L-selectin and peripheral lymph node addressin (PNAd) and the other via α4β7 integrin and mucosal addressin cell adhesion molecule 1 (MAdCAM-1). The present study was undertaken to elucidate the role of post-translational modification of MAdCAM-1 protein with L-selectin ligand carbohydrates in the pathogenesis of ulcerative colitis. In this study, ulcerative colitis disease activity is not regulated by expression of MAdCAM-1 protein itself, but rather by decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates mediated chiefly by sulfation by GlcNAc6ST-1.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Role of ASC in the mouse model of Helicobacter pylori infection.2009
Author(s)
Benoit NB, Kobayashi M, Kawakubo M, Takeoka M, Sano K, Zou J, Itano N, Tsutsui H, Noda T, Sagara J, Fukuda M, Nakayama J, Taniguchi S
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Journal Title
J Histochem Cytochem 57
Pages: 327-338
Related Report
Peer Reviewed
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[Presentation] Laminin-binding glycans attached toα-dystroglycan function as a novel tumor suppressor.2008
Author(s)
Bao X, Kobayashi M, Hatakeyama S, Yu SY, Angata K, Gullberg D, Khoo KH, Nakayama J, Fukuda MN, Fukuda M
Organizer
Annual Conference of the Society for Glycobiology
Place of Presentation
Fort Worth, TX, USA
Related Report
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