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The clinicopathological analysis of refractory classical Hodgkin lymphoma

Research Project

Project/Area Number 20790279
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionShinshu University

Principal Investigator

ASANO Naoko  Shinshu University, 医学部附属病院, 病院助教 (90467192)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsホジキンリンパ腫 / 臨床病理学的検討 / 治療抵抗性 / EBV / 細胞障害性分子 / 高齢者 / 悪性リンパ腫 / 細胞傷害性分子 / EBウイルス
Research Abstract

Classical Hodgkin lymphoma (CHL) is characterized by Hodgkin and Reed Sternberg (H-RS) cells, which are of B-cell origin in many cases. Rare cases show the unusual phenotypic features, including cytotoxic molecule(CM)-positive. Here, we document the clinicopathologic profiles of 32 patients with CM-positive CHL (20 men and 12 women ; median age 50 years, range 19 to 81 years). H-RS cells of CM-positive CHL patients had a prototypic immunophenotype of CD15+CD30+CD45RO-fascin+, with infrequent T-cell marker positivity and positivity for Epstein-Barr virus in 38% of cases. All patients were negative for Pax5. In comparison with CM-positive nodal peripheral T-cell lymphomas of not otherwise specified type (PTCL-N), CM-positive CHL cases had relatively mild clinical symptoms similar to CM-negative CHL. Regarding prognosis, the survival curve of CM-positive CHL was worse than that of CM-negative CHL(P=.0003)and better than that of CM-positive PTCL-N(P=.002).CM-positive CHL is characterized by an unfavorable prognosis, even if its clinicopathological features are within the boundaries of CHL. CHL is divided into four histological subgroups, nodular sclerosis (NSCHL), mixed cellularity (MCCHL), lymphocyte-rich, and lymphocyte depletion. While NSCHL in young adults is characterized by a mediastinal mass and good prognosis, the clinicopathological characteristics of NSCHL in the elderly(NSCHL-e)remain uncertain. To better characterize NSCHL-e, we compared the clinicopathological profiles of 84 NSCHL-e patients(>50y.o.)with237NSCHL-y patients(<50y.o.).NSCHL-e is characterized by an unfavorable prognosis and different clinicopathological features when compared to NSCHL-y, which is considered as typical NSCHL. Some of NSCHL-e cases had atypical phenotypic HRS cells, namely CD20-positive, CM-positive, and EBV-positive ones. The prognosis of NSCHL-e was poorer than that of NSCHL-y(P<0.001).

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (32 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (19 results) Book (2 results)

  • [Journal Article] A case of systemic anaplastic large cell lymphoma with 'Hodgkin-like' appearance and skin involvement mimicking lymphomatoid papulosis.2011

    • Author(s)
      Kiniwa Y, Ide Y, Fukushima M, Asano N, Saida T.
    • Journal Title

      J Cutan Pathol. 38(1)

      Pages: 38-42

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma2010

    • Author(s)
      Asano N, Suzuki R, Ohshima K, Kagami Y, Ishida F, et al.
    • Journal Title

      Int J Hematol. 91(3)

      Pages: 426-435

    • NAID

      10026401157

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma2010

    • Author(s)
      Naoko Asano
    • Journal Title

      Int J Hematol.

      Volume: 96 Pages: 426-435

    • NAID

      10026401157

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus2010

    • Author(s)
      浅野直子
    • Journal Title

      病理と臨床(臨時増刊号)

      Volume: 28 Pages: 320-321

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Age-related EBV associated B-cell lymphoproliferative disorders:これまでの研究成果と今後の課題2010

    • Author(s)
      浅野直子
    • Journal Title

      血液・腫瘍科

      Volume: 61 Pages: 21-23

    • Related Report
      2010 Annual Research Report
  • [Journal Article] DLBCLの新項目:加齢性EBV関連B細胞リンパ増殖異常症2010

    • Author(s)
      浅野直子
    • Journal Title

      病理と臨床

      Volume: 28 Pages: 741-743

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Age-related Epstein-Barr virus (EBV)-associated B-cell lymphoproliferativedisorders : comparison with EBV-positive classic Hodgkin lymphoma in elderly patients.2009

    • Author(s)
      Asano N, Yamamoto K, Tamaru J, Oyama T, Ishida F, et al.
    • Journal Title

      Blood. 113(12)

      Pages: 2629-2636

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders : diagnostic approach to a newly recognized clinicopathological entity.2009

    • Author(s)
      Shimoyama Y, Asano N, Kojima M, Morishima S, Yamamoto K, et al.
    • Journal Title

      Pathol Int. 59(12)

      Pages: 835-843

    • NAID

      10027382347

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 加齢性EBV関連B細胞リンパ増殖異常症:高齢者ポジキンリンパ腫との比較2009

    • Author(s)
      浅野直子
    • Journal Title

      血液・腫瘍科 59(4)

      Pages: 445-449

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Grey zone lymphomaとは何か2009

    • Author(s)
      浅野直子
    • Journal Title

      血液・腫瘍科 58(5)

      Pages: 553-557

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Age-related Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders : comparison with EBV-positive classic Hodgkin lymphoma in elderly patients2009

    • Author(s)
      Naoko Asano
    • Journal Title

      Blood 113(12)

      Pages: 2629-2636

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Clinicopathological features of nodular sclerosis-type classical Hodgkin lymphoma in the elderly2010

    • Author(s)
      浅野直子
    • Organizer
      アメリカ血液学会(ASH)
    • Place of Presentation
      オーランド
    • Year and Date
      2010-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinicopathological features of nodular sclerosis-type classical Hodgkin lymphoma in the elderly2010

    • Author(s)
      Naoko Asano
    • Organizer
      ASH2010
    • Place of Presentation
      オーランド(アメリカ)
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nodular Screlosis type classical Hodgkin lymphoma in the elderly2010

    • Author(s)
      浅野直子
    • Organizer
      国際ホジキンシンポジウム(ISHL)
    • Place of Presentation
      ケルン
    • Year and Date
      2010-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Nodular sclerosis-type classical Hodgkin lymphoma in the elderly2010

    • Author(s)
      Naoko Asano
    • Organizer
      ISHL2010
    • Place of Presentation
      ケルン(ドイツ)
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高齢者発症結節硬化型ホジキンリンパ腫の臨床病理学的検討2010

    • Author(s)
      浅野直子
    • Organizer
      日本血液学会総会(プレナリー)
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 中高齢者発症の結節硬化型ホジキンリンパ腫の臨床病理学的検討2010

    • Author(s)
      浅野直子
    • Organizer
      日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] EBV-positive DLBCL of the elderly2010

    • Author(s)
      浅野直子
    • Organizer
      comparison with EBV+CHL日本病理学会総会(学術奨励賞受賞)
    • Place of Presentation
      東京
    • Year and Date
      2010-04-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Age-related EBV-associated Lymphoproliferative disorders : compared with EBV-positive classical Hodgkin lymphoma2010

    • Author(s)
      浅野直子
    • Organizer
      日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] EBV-positive DLBCL of the elderly2010

    • Author(s)
      浅野直子
    • Organizer
      comparison with EBV+CHL 2010 Malignant lymphoma Academy
    • Place of Presentation
      東京
    • Year and Date
      2010-03-13
    • Related Report
      2010 Final Research Report
  • [Presentation] EBV-positive DLBCL of the elderly : Compared with EBV-positive classical Hodgkin lymphoma of the elderly2010

    • Author(s)
      Naoko Asano
    • Organizer
      2010 Malignant Lymphoma Academy
    • Place of Presentation
      Hotel Okura (Tokyo)
    • Year and Date
      2010-03-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cytotoxic molecule positive classical Hodgkin lymphoma2009

    • Author(s)
      浅野直子
    • Organizer
      アメリカ血液学会(ASH)
    • Place of Presentation
      ニューオーリンズ
    • Year and Date
      2009-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Cytotoxic molecule-positive classical Hodgkin lymphoma2009

    • Author(s)
      Naoko Asano
    • Organizer
      51st ASH Annual Meeting and Exposition
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cytotoxic molecule positive classical Hodgkin lymphoma2009

    • Author(s)
      浅野直子
    • Organizer
      第10回日韓リンパ網内系ワークショップ
    • Place of Presentation
      福島
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Cytotoxic molecule-positive classical Hodgkin lymphoma2009

    • Author(s)
      Naoko Asano
    • Organizer
      The 10th Japanese-Korean Lymphoreticular Workshop
    • Place of Presentation
      Fukushima View Hotel (Fukushima)
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加齢性EBV関連B細胞増殖疾患と高齢者でのEBV陽性Hodgkinリンパ腫の比較2009

    • Author(s)
      浅野直子
    • Organizer
      第5回麒麟塾
    • Place of Presentation
      コクヨホール(東京)
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hodgkin lymphoma & gray zone lymphoma2009

    • Author(s)
      浅野直子
    • Organizer
      日本リンパ網内系学会
    • Place of Presentation
      淡路
    • Year and Date
      2009-07-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Hodgkin & Gray zone Iymphoma病理医の立場から2009

    • Author(s)
      浅野直子
    • Organizer
      日本リンパ網内系学会総会
    • Place of Presentation
      淡路島
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ホジキンリンパ腫EBV発現とその関連疾患2008

    • Author(s)
      浅野直子
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] ホジキンリンパ腫EBV発現とその関連疾患2008

    • Author(s)
      浅野直子
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢石川県立音楽堂
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Book] WHO血液腫瘍分類~WHO分類2008をうまく活用するために~2010

    • Author(s)
      中村栄男, 等(編)
    • Publisher
      医薬ジャーナル社
    • Related Report
      2009 Annual Research Report
  • [Book] WHO血液腫瘍分類~WHO分類2008をうまく活用するために~(EBV-positive DLBCL of the elderly, B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and CHL, Anaplastic large cell lymphoma, ALK-negative, Classical Hodgkin lymphoma)(浅野直子)

    • Author(s)
      直江知樹、中村栄男, 等編
    • Publisher
      医薬ジャーナル
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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