| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
This is the first study to compare stable human liver allografts versus chronically rejected allografts in the long-term after liver transplantation from the viewpoint of genomic instability, specially telomere shortening, chimerism, and aneuploidy. The telomere decline at 10 years post-transplant, the telomere decline rate at the first year after transplantation, and hepatocellular aneuploidy at 10 years post-transplant were seen greater in rejection group than those of stable group, although advanced aneuploidy and telomere shortening for the presumed allograft age was seen in both groups.
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