Analysis of decoy receptors in osteoblastogenesis and osteoclastogenesis : a role in prostate cancer and its bone metastasis
| Project/Area Number |
20790283
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Kobe University |
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Principal Investigator |
KONDO Takeshi 神戸大学, 大学院・医学研究科, 講師 (20335441)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | BAMBI / TGF-b / BMP / pseudoreceptor / TGF-β |
|---|
| Research Abstract |
In vitro studies revealed that BAMBI mRNA expression significantly increased during osteoblastic differentiation. It was suggested that BAMBI expression plays an important role as part of the negative feedback loop system in TGF-β/BMP signaling and BAMBI is regulated by both TGF-β/BMP and Wnt/β-catenin signaling pathways. I then assessed the methylation status of the BAMBI promoter region and found tissue-specific distribution of promoter hypermethylation. It is therefore speculated that the epigenetic regulation of BAMBI gene expression by CpG hypermethylation is physiologically involved in tissue-and development-specific BAMBI expression. BAMBI is a target gene of both BMP and Wnt/β-catenin signaling and may be involved in preventing some of the osteoblast precursors from terminal differentiation
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Report
(6 results)
Research Products
(32 results)
