Roles of a disintegrin and metalloproteinases (ADAMs) in inflammatory bowel diseases

• Project/Area Number: 20790291
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Keio University
• Principal Investigator: SHIMODA Masayuki Keio University, 医学部, 助教 (70383734)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 病理学 / 細胞・組織 / 炎症 / 大腸

Research Abstract

In this study, the roles of ADAMs in inflammatory bowel diseases are investigated. In vitro induction experiments, ADAM28 was induced by inflammatory cytokines and enhanced the HL-60 cell binding to P-selectin-coated wells. On the other hand, ADAM17flox/flox/MX1-Cre+ mice were highly susceptible to the development of colitis induced by DSS compared with wild type mice, which might be due to increased colonic mucosa destruction. These data suggest that ADAMs may play significant roles in regulating the inflammation and regeneration in inflammatory bowel diseases.

Research Products

• [Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers (2010)
  • Author(s): Kuroda H, Mochizuki S, Shimoda M, Chijiiwa M, Kamiya K, Izumi Y, Watanabe M, Horinouchi H, Kawamura M, Kobayashi K, Okada Y.
  • Journal Title: Int. J. Cancer (in press)
• [Journal Article] ADAM28 is a serological and histochemical marker for non-small-cell lung cancers (2010)
  • Author(s): Kuroda H, Mochizuki S, Shimoda M, Chijiiwa M, Kamiya K, Izumi Y, Watanabe M, Horinouchi H, Kawamura M, Kobavashi K, Okada Y
  • Journal Title: Int.J.Cancer (In press)
  • Peer Reviewed
• [Journal Article] Amyloid-・ causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons (2009)
  • Author(s): Chiba T, Yamada M, Sasabe J, Terashita K, Shimoda M, Matsuoka M, Aiso S
  • Journal Title: Mol. Psychiatry 14 Pages: 206-222
• [Journal Article] Multiple Aneurysms of the Splenic Artery Caused by Fibromuscular Dysplasia (2009)
  • Author(s): Watada S, Obara H, Shimoda M, Matsubara K, Matsumoto K, Kitajima M
  • Journal Title: Ann. Vasc. Surg. 23
• [Journal Article] Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons (2009)
  • Author(s): Chiba T, Yamada M, Sasabe J, Terashita K, Shimoda M, Matsuoka M, Aiso S
  • Journal Title: Molecular Psychiatry 14 Pages: 206-222
  • Peer Reviewed
• [Journal Article] Expression of Heparanase in Renal Cell Carcinomas: Implications for Tumor Invasion and Prognosis (2008)
  • Author(s): Mikami S, Oya M, Shimoda M, Mizuno R, Ishida M, Kosaka T, Mukai M, Nakajima M, Okada Y
  • Journal Title: Clin. Cancer Res. 14 Pages: 6055-6061
• [Journal Article] Primary invasive micropapillary carcinoma of the stomach (2008)
  • Author(s): Shimoda M, Okada Y, Hayashi Y, Hatano S, Kawakubo H, Omori T, Ishii S, Sugiura H
  • Journal Title: Pathol. Int. 58 Pages: 513-517
  • NAID: 10027377498
• [Journal Article] Expression of Heparanase in Renal Cell Carcinomas : Implications for Tumor Invasion and Prognosis (2008)
  • Author(s): Mikami S, Oya M, Shimoda M. Mizuno R, Ishida M, Kosaka T Mukai M, Nakajima M, Okada Y
  • Journal Title: Clinical Cancer Research 14 Pages: 6055-6061
  • Peer Reviewed
• [Journal Article] Primary invasive micropapillary carcinoma of the stomach (2008)
  • Author(s): Shimoda M, Okada Y, Hayashi Y, Hatano S, Kawakubo H, Omori T, Ishii S, Sugiura H
  • Journal Title: Pathology International 58 Pages: 513-517
  • NAID: 10027377498
  • Peer Reviewed
• [Presentation] Induction of ADAM28 in endothelial cells at inflammatory sites enhances leukocyte adhesion to endothelial cells (2008)
  • Author(s): Shimoda M, Okada Y
  • Organizer: The XXIth Federation of European Connective Tissue Societies meeting
  • Place of Presentation: Marseille (France)
  • Year and Date: 2008-07-10
• [Presentation] ADAM28の血管内皮細胞による発現と機能解析 (2008)
  • Author(s): 下田将之、岡田保典
  • Organizer: 第97回日本病理学会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-17
• [Presentation] Induction of ADAM28 in endothelial cells at inflammatory sites enhances leukocyte adhesion to endothelial cells (2008)
  • Author(s): Shimoda M, Okada Y
  • Organizer: The XXIth Federation of European Connective Tissue Societies meeting
  • Place of Presentation: Marseille, France
• [Presentation] がん細胞-血管内皮細胞接着におけるADAM28の役割解析 (2008)
  • Author(s): 下田将之
  • Organizer: 第17回日本がん転移学会
  • Place of Presentation: 鹿児島
• [Book] 「MMP/ADAM」、『炎症・再生医学事典(松島綱治、西脇徹編)』 (2009)
  • Author(s): 下田将之、岡田保典
  • Publisher: 朝倉書店出版
• [Book] 「癌細胞-細胞外基質への接着能の測定法」、『がん転移研究の実験手法(済木育夫、愛甲孝編) (2008)
  • Author(s): 下田将之、岡田保典
  • Publisher: 金芳堂出版