| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Focusing on lung cancers with ALK translocation, we have been attempting to establish the appropriate method to detect EML4-ALK lung cancers, to detect their new variants, to analyze the clinicopathologic and genetic characteristics of them, and to find out the other ALK translocated lung cancers. We have identified novel variants for EML-ALK fusion gene with cDNA screening and multiplex RT-PCR. We have found out that EML4-ALK lung cancers are characterized by rare other mutations, TTF-1 cell lineage, less-differentiated acinar histology with mucin, young onset, and non- or light smoking status. Furthermore, by developing a sensitive immunohistochemical method appropriate for detecting ALK translocation, we have discovered KIF5B-ALK, a novel fusion oncokinase, in lung cancers.
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