The clinicopathologic and genetic analysis of lung cancers with ALK translocation
| Project/Area Number |
20790293
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
INAMURA Kentaro Japanese Foundation For Cancer Research, 病理部, 研究員 (40442545)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肺癌 / EML4-ALK / 遺伝子変異 / 病理 / 免疫組織化学 / RT-PCR |
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| Research Abstract |
Focusing on lung cancers with ALK translocation, we have been attempting to establish the appropriate method to detect EML4-ALK lung cancers, to detect their new variants, to analyze the clinicopathologic and genetic characteristics of them, and to find out the other ALK translocated lung cancers. We have identified novel variants for EML-ALK fusion gene with cDNA screening and multiplex RT-PCR. We have found out that EML4-ALK lung cancers are characterized by rare other mutations, TTF-1 cell lineage, less-differentiated acinar histology with mucin, young onset, and non- or light smoking status. Furthermore, by developing a sensitive immunohistochemical method appropriate for detecting ALK translocation, we have discovered KIF5B-ALK, a novel fusion oncokinase, in lung cancers.
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Report
(3 results)
Research Products
(56 results)
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[Journal Article] EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset2009
Author(s)
Inamura K, Takeuchi K, Togashi Y, Hatano S, Ninomiya H, Motoi N, Mun MY, Sakao Y, Okumura S, Nakagawa K, Soda M, Choi YL, Mano H, Ishikawa Y.
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Journal Title
Mod Pathol 22(4)
Pages: 508-15
Related Report
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[Journal Article] KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer.2009
Author(s)
Takeuchi K, Choi YL, Togashi Y, Soda M, Hatano S, Inamura K, Takada S, Ueno T, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y, Mano H.
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Journal Title
Clin Cancer Res. 15(9)
Pages: 3143-9
Related Report
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[Journal Article] EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers2008
Author(s)
Inamura K, Takeuchi K, Togashi Y, Nomura K, Ninomiya H, Okui M, Satoh Y, Okumura S, Nakagawa K, Soda M, Choi YL, Niki T, Mano H, Ishikawa Y.
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Journal Title
J Thorac Oncol. 3(1)
Pages: 13-7
Related Report
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[Journal Article] Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer2008
Author(s)
Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H.
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Journal Title
Cancer Res. 68(13)
Pages: 4971-6
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[Journal Article] Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts.2008
Author(s)
Takeuchi K, Choi YL, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Takada S, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y, Mano H.
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Journal Title
Clin Cancer Res. 14(20)
Pages: 6618-24
Related Report
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