Development of a logistic regression predictive model for the outcome of patients with resected lung adenocarcinoma of 2cm or less in size

• Project/Area Number: 20790294
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Kanagawa Cancer Center Research Institute
• Principal Investigator: SAKUMA Yuji Kanagawa Cancer Center Research Institute, 神奈川県立がんセンター(臨床研究所)・がん分子病態研究部門, 主査 (10364514)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 小型肺腺癌 / 術後再発 / アポトーシス / 予後予測式 / 脈管浸潤

Research Abstract

本研究では、最大径2cm以下の小型肺腺癌の術後再発を概ね正確に予想するため判別式を作製することができた。さらに術後再発を規定する最大の因子は脈管浸潤の有無であったため、脈管内に浸潤した肺腺癌細胞をアポトーシス(細胞死)させるための研究も併せて行い、Srcの活性化が肺腺癌のアポトーシス抵抗性に関与していることを示すことができた。

Research Products

• [Journal Article] Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated (2010)
  • Author(s): Sakuma Y, Takeuchi T, Nakamura Y, Yoshihara M, Matsukuma S, Nakayama H, Ohgane N, Yokose T, Kameda Y, Tsuchiya E, Miyagi Y.
  • Journal Title: J Pathol 220 Pages: 574-585
• [Journal Article] Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated Src (2010)
  • Author(s): Sakuma Y, et al.
  • Journal Title: The Journal of Pathology 220 Pages: 574-585
  • Peer Reviewed
• [Journal Article] A logistic regression predictive model and the outcome of patients with resected lung adenocarcinoma of 2cm or less in size. (2009)
  • Author(s): Sakuma Y, Okamoto N, Saito H, Yamada K, Yokose T, Kiyoshima M, Asato Y, Amemiya R, Saitoh H, Matsukuma S, Yoshihara M, Nakamura Y, Oshita F, Ito H, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y.
  • Journal Title: Lung Cancer 65 Pages: 85-90
• [Journal Article] A logistic regression predictive model and the outcome of patients with resected lung adenocarcinoma of 2cm or less in size (2009)
  • Author(s): Sakuma Y, et al.
  • Journal Title: Lung Cancer 65 Pages: 85-90
  • Peer Reviewed
• [Presentation] Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing Src (2009)
  • Author(s): Sakuma Y, et al.
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing Src. (2009)
  • Author(s): Sakuma Y, Takeuchi T, Nakamura Y, Yoshihara M, Matsukuma S, Yokose T, Kameda Y, Tsuchiya E, Miyagi Y.
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 横浜・パシフィコ横浜
• [Presentation] 予後不良の小型肺腺癌の特徴を明らかにするための研究 (2008)
  • Author(s): 佐久間裕司、中村圭靖、亀田陽一、横瀬智之、土屋永寿、宮城洋平
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢・石川県立音楽堂