Elucidation of oncolytic mechanisms of sindbis virus
| Project/Area Number |
20790297
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Chiba University |
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Principal Investigator |
SAITO Kengo Chiba University, 大学院・医学研究院, 助教 (70451755)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腫瘍 / シンドビスウイルス / 腫瘍溶解 / 構造蛋白 / 癌 / ウイルス |
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| Research Abstract |
I identified sindbis virus (SIN) has remarkable oncolytic effects on human cancer cell lines, and examined the involvement of the major components of SIN structural proteins, capsid, E2, and E1, in the oncolysis. E1 was shown to play an important role in the oncolysis. This finding suggested that the E1 protein may be used as an agent for cancer therapy.
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Report
(3 results)
Research Products
(11 results)
