| Project/Area Number |
20790298
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIYAZAKI Miki The University of Tokyo, 大学院・医学系研究科, 特任研究員 (30401912)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | エピジェネティクス / 癌 / L(3)MBT |
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| Research Abstract |
It has been shown that epigenetic regulation of gene expression plays important roles in a variety of biological actions, such as cell proliferation, differentiation as well as maintenance of the purlipotency of the stem cells. In this study, we focused on L(3)MBT, one of the polycomb group proteins, and tried to investigate L(3)MBT deficient mice to know the physiological function of L(3)MBT and influences caused by its dysfunction. As conventional L(3)MBT-null mice died in the early embryonic phase, a conditional targeting vector which can be used for inducible deletion of the gene were prepared. ES cells which performed homologous recombination with the vector were obtained, and the chimeric mice were generated from the ES cells.
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