| Project/Area Number |
20790299
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HEMMI Hiroaki Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 (20451924)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子 / 樹状細胞 / マクロファージ / サイトカイン産生 / 死細胞 / サブセット / イムノグロブリンスパーファミリー |
|---|
| Research Abstract |
Triggering receptor expressed on myeloid cells (Trem) family is known to regulate activation status of immune cells. In this study, we tried to uncover the function of a newly identified Trem molecule. It has been reported that the expression levels of other Trem members are up-regulated or down-regulated when the cells were activated. However, the expression of this molecule on dendritic cells (DCs) was not altered after their activation. In addition, the results from analyses of gene-knocked out mice suggest that this molecule is not involved in uptake of apoptotic cells by DCs. On the other hand, gene knocked-out mice showed slightly enhanced responses in terms of cytokine productions and antibody induced arthritis, suggesting that this molecule may be negatively involved in inflammatory responses.
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