| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
The presence of cancer stem cells in murine colon tumors was investigated, focusing on the common characteristics with tissue stem cells. Firstly, we examined the underling mechanisms on the control of cellular differentiation and proliferation in the normal colon epithelium and found that the induction of higher level of β-catenin induced the colonic stem cells dividing slowly. Next, we examined the expression pattern of β-catenin in murine colon tumors and found the cells expressing a higher level of β-catenin and dividing more slowly than surrounding tumor cells, indicating the presence of cancer stem-like cells in murine colon tumors.
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