ENROLEMENT OF THE CYCOLPHILIN IN THE REACTIVATION OF CYTOMEGALOVIRUS IN STEM CELLS

• Project/Area Number: 20790301
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: KAWASAKI Hideya Hamamatsu University School of Medicine, 医学部・病理学第二講座, 助教 (90397381)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: サイトメガロウイルス / シクロフィリン / 幹細胞 / ES細胞 / 神経幹細胞

Research Abstract

Susceptibility of CMV depends on differentiation process of the cells. We hypothesized that the susceptibility to CMV may highly dependent on CMV IE promoter. According to the hypothesis we have proceeded the experiment to reveal the relationship between cyclophilin and MCMV IE promoter. Unexpectedly we have found that ES is the cell showing the resistance to CMV genome entry into the cell nucleus. Now we are doing the experiment to find the mechanism of the resistance to CMV in ES.

Research Products

• [Journal Article] Aggressive progression of breast cancer with microscopic pulmonary emboli possessing a stem cell-like phenotype independent of its origin (2010)
  • Author(s): Kawasaki H, Ogura H, Arai Y, Baba S, Kosugi I, Tsutsui Y, Iwashita T.
  • Journal Title: Pathol Int. 60(3) Pages: 228-34
  • NAID: 10029331202
  • Peer Reviewed
• [Journal Article] Induction of cytomegalovirus-infected labyrinthitis in newborn mice by lipopolysaccharide: a model for hearing loss in congenital CMV infection (2008)
  • Author(s): Li L, Kosugi I, Han GP, Kawasaki H, Arai Y, Takeshita T, Tsutsui Y.
  • Journal Title: Lab Invest 88(7) Pages: 722-30
  • Peer Reviewed
• [Journal Article] A case of primary cutaneous natural killer/T-cell lymphoma, nasal type, directly invading to the heart (2008)
  • Author(s): Kawasaki H, Shigeno K, Ohnishi K, Tsuchida T, Miura K, Kato T, Kosugi I, Tsutsui Y
  • Journal Title: Leuk Lymphoma 49(5) Pages: 1008-11
  • Peer Reviewed
• [Journal Article] Roles of neural stem progenitor cells in cytomegalovirus infection of the brain in mouse models (2008)
  • Author(s): Tsutsui Y, Kosugi I, Kawasaki H, Arai Y, Han GP, Li L, Kaneta M
  • Journal Title: Pathol Int. 58(5) Pages: 257-67
  • NAID: 10027376380
  • Peer Reviewed
• [Journal Article] Induction of cytomegalovirus-infected labyrinthitis in newborn mice bylipopolysaccharide : a model for hearing loss in congenital CMV infection (2008)
  • Author(s): Li L, Kosugi I, Han GP, Kawasaki H, Arai Y, Takeshita T, Tsutsui Y.
  • Journal Title: Laboratory Investigation 88 Pages: 722-30
  • Peer Reviewed
• [Journal Article] A case of primary cutaneous natural killer/T-cell lymphoma, nasal type, directly invading to the heart (2008)
  • Author(s): Kawasaki H, Shigeno K, Ohnishi K, Tsuchida T, Miura K, Kato T. Kosugi I. Tsutsui Y.
  • Journal Title: Leukemia Lymphoma 49 Pages: 1008-11
  • Peer Reviewed
• [Journal Article] Roles of neural stem progenitor cells in cytomegalovirus infection of the brain in mouse models (2008)
  • Author(s): Tsutsui Y, Kosugi I, Kawasaki H, Arai Y, Han GP, Li L, Kaneta M.
  • Journal Title: Pathology International 58 Pages: 257-67
  • NAID: 10027376380
  • Peer Reviewed
• [Presentation] ES細胞におけるサイトメガロウイルス感染感受性獲得への多段階的制御 (2009)
  • Author(s): 河崎秀陽
  • Organizer: ウイルス学会
  • Place of Presentation: 都市センターホテル
  • Year and Date: 2009-10-25
• [Presentation] ES細胞におけるサイトメガロウイルス感染感受性の多段階的制御 (2009)
  • Author(s): 河崎秀陽
  • Organizer: ウイルス学会
  • Place of Presentation: 都市センターホテル
  • Year and Date: 2009-10-25
• [Presentation] ES細胞におけるサイトメガロウイルス感染感受性獲得への多段階的制御 (2009)
  • Author(s): 河崎秀陽
  • Organizer: 病理学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-02
• [Presentation] 神経系細胞におけるクロマチンリモデリングとサイトメガロウイルス感染感受性 ; 脳におけるHDAC分布との関係 (2008)
  • Author(s): 河崎秀陽、小杉伊三夫、新井義文、李立、筒井祥博
  • Organizer: 日本病理学会
  • Place of Presentation: ホテル日航金沢
  • Year and Date: 2008-05-06