The role of c-KIT positive cancer cells in a drug resistance of the intestinal tumors
Project/Area Number |
20790303
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
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Research Institution | Kyoto University |
Principal Investigator |
KITAMURA Takanori Kyoto University, 医学研究科, 助教 (10378622)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 腫瘍・マウスモデル・大腸癌 / c-KIT / 抗癌剤 / 大腸癌 |
Research Abstract |
Apc/Smad4 compound mutant mice develop intestinal adenocarcinomas with marked tumor invasion. We demonstrated here that cancer cells at the invasion fronts expressed a progenitor cell marker c-KIT. Although 5-fluorouracil treatments retracted the invasive adenocarcinomas, the c-KIT positive cancer cells did not disappeared from the tumors in contrast to the c-KIT negative cells. These results suggest that the c-KIT positive cells are resistant to 5-fluorouracil treatments.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis.2009
Author(s)
Du YC, Oshima H, Oguma K, K itamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Kotani H, Taketo MM, Oshima M
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Journal Title
Gastroenterology 137(4)
Pages: 1346-1357
Related Report
Peer Reviewed
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