| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Glioblastoma is the most malignant brain tumor with very poor prognosis. I aimed to identify novel functional genes influencing the malignant features of glioblastoma by analyzing some genes overexpressed by glioblastomas whose detailed functions remain unknown. In this study, I focused on IGFBP-2 and CD24, both of which were involved in the invasive growth of glioblastoma. The cDNA microarrays for transcriptional profiling revealed significantly reduced expression of progression-associated genes and enhanced expression of suppression-associated genes in response to IGFBP-2 or CD24 knockdown in glioblastoma cell lines. Furthermore, about 30 functional genes were identified as candidates for positive regulators of IGFBP-2 by an expression cloning method. These genes and the related signal transductions serve as potential therapeutic targets in glioblastoma.
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