| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We generated a medaka model capable of allowing the observation of various cell behaviors of transplanted tumors cells, such as cell proliferation and metastasis, which were visualized easily in vivo. Medaka melanoma cells stably expressing green fluorescence protein were established and transplanted into medaka with same genetic background. We could easily visualize tumor growth and metastasis of the transplanted cells at a single level resolution in vivo. Our medaka model provides an opportunity to visualize in vivo tumor cells "as seen in a culture dish" and would be useful for in vivo tumor cell biology.
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