Role of β-catenin in the liver and liver cancer
Project/Area Number |
20790315
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
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Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
Principal Investigator |
SEKINE Shigeki National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所病理部, 室長 (10321879)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | β-catenin / 肝 / 肝がん |
Research Abstract |
To systematically identify β-catenin-regulated genes in the liver, a microarray analysis was performed on hepatocyte-specific β-catenin knockout mice. The expression of the identified β-catenin downstream genes were further examined in human hepatocellular carcinoma samples. The result showed that overexpression of a subset of the β-catenin-regulated genes identified in the mouse models correlated closely with the presence of β-catenin gene mutations in human hepatocellular carcinomas. Hepatocyte-specific Dicer knockout mice was found to exhibit impaired localization of periportal genes within the liver lobule. This phenotype partially simulates that of β-catenin knockout mice. Analysis of these two mouse models revealed an essential role of Dicer in the regulation of periportal area-specific gene expression by β-catenin.
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Report
(3 results)
Research Products
(2 results)