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Expression of transcription factors and epithelial-mesenchymal interaction in intestinal metaplasia of Helicobacter pyloriinfected gastric mucosa

Research Project

Project/Area Number 20790318
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

TOYODA Takeshi  Aichi Cancer Center Research Institute, 腫瘍病理学部, 研究員 (50443453)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsヘリコバクター・ピロリ / スナネズミ / 胃癌 / Helicobacter pylori / 腸上皮化生 / 転写因子 / 上皮間充織相互作用
Research Abstract

ヘリコバクター・ピロリ(ピロリ菌)感染は慢性胃炎/胃癌の発生に深く関与する。本研究ではスナネズミにピロリ菌を感染させ、胃粘膜に与える影響とそのメカニズムについて解析を行った。1年間の経過観察後、病理標本の詳細な観察に基づき胃癌の発生した個体、あるいは典型的な慢性胃炎を示す個体を抽出した。また、炎症に関与する種々の遺伝子の変化を調べ、ピロリ菌感染胃粘膜における背景データを得た。今後、胃粘膜を上皮と間質に分けて解析し、病変の進行(特に腸型化)に影響する因子について検討を加える予定である。

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (47 results)

All 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (22 results) Book (9 results)

  • [Journal Article] Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells.2010

    • Author(s)
      Niwa T, Toyoda T, 3番目, et al., 他7名
    • Journal Title

      Cancer Res 70

      Pages: 1430-1440

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells2010

    • Author(s)
      Niwa T, et al.
    • Journal Title

      Cancer Res. 70

      Pages: 1430-1440

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pitavastatin fails to lower serum lipid levels or inhibit gastric carcinogenesis in Helicobacter pylori-infected rodent models.2009

    • Author(s)
      Toyoda T(1番目), et al., (他8名)
    • Journal Title

      Cancer Prev Res 2

      Pages: 751-758

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-κB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils.2009

    • Author(s)
      Toyoda T(1番目), et al., (他7名)
    • Journal Title

      Int J Cancer 125

      Pages: 1786-1795

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pitavastatin fails to lower serum lipid levels or inhibit gastric carcinogenesis in Helicobacter pylori-infected rodent models2009

    • Author(s)
      Toyoda T, et al.
    • Journal Title

      Cancer Prev.Res. 2

      Pages: 751-758

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-κB inhibitor, on Helicobacter pylori=induced gastritis in Mongoliangerbils2009

    • Author(s)
      Toyoda T, et al.
    • Journal Title

      Int.J.Cancer 125

      Pages: 1786-1795

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic observation of N-methyl-N'-nitro-N-nitrosoguanidine-inducedgastric carcinogenesis in rat using a newly-developed flexible endoscope2009

    • Author(s)
      Kondo S, et al.
    • Journal Title

      Asian Pac.J.Cancer Prev. 10

      Pages: 883-886

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of osteopontin and CDX2: Indications of phenotypes and prognosis in advanced gastric cancer2009

    • Author(s)
      Zhang X, et al.
    • Journal Title

      Oncol. Rep. 21

      Pages: 609-613

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic upregulation of inducible nitric oxide synthase and cyclooxygenase-2 in gastric mucosa of Mongolian gerbils by a high-salt diet and Helicobacter pylori infection.2008

    • Author(s)
      Toyoda T(1番目), et al., (他7名)
    • Journal Title

      Histol Histopathol 23

      Pages: 593-599

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of carcinoid tumors of the glandular stomach and effects of eradication in Helicobacter pylori-infected Mongolian gerbils.2008

    • Author(s)
      Cao L, Toyoda T(5番目), et al., (他7名)
    • Journal Title

      Asian Pac J Cancer Prev 9

      Pages: 25-30

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 4-Vinyl-2, 6-dimethoxyphenol (Canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils.2008

    • Author(s)
      Cao X, Toyoda T(9番目), et al., (他9名)
    • Journal Title

      Int J Cancer 122

      Pages: 1445-1454

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic upregulation of inducible nitric oxide synthase and cyclooxygenase-2 in gastric mucosa of Mongolian gerbils by a high-salt diet and Helicobacter pylori infection2008

    • Author(s)
      Toyoda T, et al.
    • Journal Title

      Histol. Histopathol. 23

      Pages: 593-599

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4-Vinyl-2, 6-dimethoxyphenol (Canolol) suppresses oxidative stress and carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils2008

    • Author(s)
      Cao X, et al.
    • Journal Title

      Int. J. Cancer 122

      Pages: 1445-1454

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of carcinoid tumors of the glandular stomach and effects of eradication in Helicobacter pylori-infected Mongolian gerbils2008

    • Author(s)
      Cao L, et al.
    • Journal Title

      Asian Pac. J. Cancer Prev. 9

      Pages: 25-30

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of fowl glioma-inducing virus in chickens of zoological gardens in Japan and uncleotide variation in the env gene2008

    • Author(s)
      Hatai H, et al.
    • Journal Title

      J. Vet. Med. Sci. 70

      Pages: 469-474

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice2008

    • Author(s)
      Takasu S, et al.
    • Journal Title

      Cancer Sci. 99

      Pages: 2356-2364

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] NF-κB阻害剤caffeic acid phenethyl ester (CAPE)のHelicobacter pylori感染スナネズミにおける慢性胃炎・胃発癌抑制効果2010

    • Author(s)
      豊田武士, 他
    • Organizer
      第26回日本毒性病理学会, 石川県立音楽堂
    • Place of Presentation
      石川県
    • Year and Date
      2010-02-04
    • Related Report
      2009 Final Research Report
  • [Presentation] NF-κB阻害剤caffeic acid phenethyl ester(CAPE)のHelicobacter pylori感染スナネズミにおける慢性胃炎・胃発癌抑制効果2010

    • Author(s)
      豊田武士, 他
    • Organizer
      第26回日本毒性病理学会
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Year and Date
      2010-02-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] NF-κB阻害剤を用いたヘリコバクター・ピロリ感染スナネズミ慢性胃炎および胃癌の抑制2009

    • Author(s)
      豊田武士, 他
    • Organizer
      第20回日本消化器癌発生学会総会
    • Place of Presentation
      オリエンタルホテル広島(広島県)
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスH.pylori感染およびMNU誘発胃腫瘍における骨髄由来細胞の関与2009

    • Author(s)
      高須伸二, 他
    • Organizer
      第20回日本消化器癌発生学会総会
    • Place of Presentation
      オリエンタルホテル広島(広島県)
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] NF-κB阻害剤caffeic acid phenethyl ester (CAPE)によるHelicobacter pylori感染スナネズミ胃発癌の抑制効果2009

    • Author(s)
      豊田武士, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] NF-κB阻害剤caffeic acid phenethyl ester(CAPE)によるHelicobacter pylori感染スナネズミ胃発癌の抑制効果2009

    • Author(s)
      豊田武士, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      オリエンタルホテル広島(広島県)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] N-methyl-N'-nitrosourea投与マウス腺胃におけるH.pylori感染と高食塩食による遺伝子発現誘導2009

    • Author(s)
      齋藤典子, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 早期胃癌発生進展における胃型・腸型形質発現の変化2009

    • Author(s)
      齋藤亜弓, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Helicobacter pyloriは炎症により胃粘膜にDNAメチル化異常を誘発する2009

    • Author(s)
      丹羽透, 豊田武士, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] スナネズミにおけるグリチルリチン酸のH.pylori感染胃炎への抑制効果2009

    • Author(s)
      曹雪源, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Helicobacter感染マウス胃癌における骨髄由来細胞の関与2009

    • Author(s)
      高須伸二, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] N-methyl-N'-nitro-N-nitrosoguanidine誘発ラット胃発癌過程の内視鏡による経時的観察2009

    • Author(s)
      近藤真也, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Helicobacter pylori感染スナネズミにおけるNIF-κB阻害剤caffeic acid phenethyl ester(CAPE)の抗炎症および腫瘍抑制効果2009

    • Author(s)
      豊田武士, 他
    • Organizer
      第24回発癌病理研究会
    • Place of Presentation
      和倉温泉(石川県)
    • Year and Date
      2009-08-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヘリコバクター・ピロリ感染スナネズミ胃癌に対するNF-κB阻害剤(CAPE)およびアスピリンの抑制効果2009

    • Author(s)
      豊田武士, 他
    • Organizer
      がん予防大会2009愛知
    • Place of Presentation
      愛知県がんセンター(愛知県)
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Helicobacter pylori感染スナネズミ腺胃化学発癌モデルからヒト胃癌の予防へ2009

    • Author(s)
      立松正衛, 他
    • Organizer
      がん予防大会2009愛知
    • Place of Presentation
      愛知県がんセンター(愛知県)
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨髄移植マウスにおけるHelicobacter感染およびMNU誘発胃癌と骨髄由来細胞の関与2009

    • Author(s)
      高須伸二, 他
    • Organizer
      がん予防大会2009愛知
    • Place of Presentation
      愛知県がんセンター(愛知県)
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Helicobacter pylori感染動物モデルにおけるピタバスタチンの胃発癌および血清脂質動態への影響2009

    • Author(s)
      豊田武士, 他
    • Organizer
      第25回日本毒性病理学会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2009-01-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Helicobacter pylori感染動物モデルにおけるピタバスタチンの胃発癌および血清脂質動態への影響2009

    • Author(s)
      豊田武士 他
    • Organizer
      第25回日本毒性病理学会
    • Place of Presentation
      浜松市
    • Year and Date
      2009-01-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスN-methyl-N-nitrosourea誘発胃がんにおけるβ-cateninの変異とH. pylori感染およびCOX-2感染が与える影響2009

    • Author(s)
      高須伸二 他
    • Organizer
      第25回日本毒性病理学会
    • Place of Presentation
      浜松市
    • Year and Date
      2009-01-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] HMG-CoA還元酵素阻害剤(ピタバスタチン)のHelicobacter pylori感染スナネズミ胃発癌に対する影響2008

    • Author(s)
      豊田武士 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] K19-C2mEトランスジェニックマウス胃癌におけるβ-cateninの蓄積と関与2008

    • Author(s)
      高須伸二 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] COX-2/mPGES-1トランスジェニックマウスにおける胃発がん性とβ-cateninの関与2008

    • Author(s)
      高須伸二 他
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      宮崎市
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Book] 細胞工学(動物感染モデルを用いたピロリ菌発癌機構解析, 29)2010

    • Author(s)
      塚本徹哉、豊田武士、溝下勤、立松正衞
    • Related Report
      2009 Final Research Report
  • [Book] Current Research in Cancer 3.(Chemoprevention of gastric cancer: lessons from an animal model.)2009

    • Author(s)
      Toyoda T, Cao X, Takasu S, Mizoshita T, Shi L, Tatematsu M, Tsukamoto T.
    • Publisher
      Research Media
    • Related Report
      2009 Final Research Report
  • [Book] Helicobacter Research(H. pylori除菌後の胃癌再発予防動物モデル)2009

    • Author(s)
      豊田武士、高須伸二、塚本徹哉、立松正衞
    • Related Report
      2009 Final Research Report
  • [Book] 胃と腸(動物実験の立場からみたHelicobacter pylori感染と胃癌, 44)2009

    • Author(s)
      豊田武士、塚本徹哉、立松正衞
    • Related Report
      2009 Final Research Report
  • [Book] Current Research in Cancer 3.(表題:Chemoprevention of gastric cancer : lessons from an animal model)2009

    • Author(s)
      Toyoda T, et al.
    • Publisher
      Research Media, India
    • Related Report
      2009 Annual Research Report
  • [Book] Helicobacter Research(表題:H.pylori除菌後の胃癌再発予防動物モデル)2009

    • Author(s)
      豊田武士, 他
    • Publisher
      先端医学社
    • Related Report
      2009 Annual Research Report
  • [Book] 胃と腸(表題:動物実験の立場からみたHelicobacter pylori感染と胃癌)2009

    • Author(s)
      豊田武士, 他
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Book] 分子細胞治療(表題:ヘリコバクター感染と胃発がん)2009

    • Author(s)
      高須伸二, 他
    • Publisher
      先端医学社
    • Related Report
      2009 Annual Research Report
  • [Book] 臨牀消化器内科(表題:食塩と胃発癌(2)食塩とH.pylori胃発癌)2009

    • Author(s)
      高須伸二, 他
    • Publisher
      日本メディカルセンター
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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