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Research of host molecules associated with the pathogenesis of severe malarial anemia

Research Project

Project/Area Number 20790322
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Parasitology (including Sanitary zoology)
Research InstitutionGunma University

Principal Investigator

HATABU Toshimitsu  Gunma University, 医学部, 助教 (60344917)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsマラリア / 貧血 / スカベンジャーレセプター / パターン認識分子
Research Abstract

Severe falciparum malaria such as cerebral malaria and severe anemia is leading cause of morbidity and mortality. Plasmodium falciparum-infected red blood cells (pRBCs) adhere to the endothelial cells via receptors expressed on the surface of the endothelial cells, sequester in the microvasculature of several organs. Severe anemia which may be due to a number of factors including rupture of the pRBCs and phagocytosis of pRBCs is another cause of death. However, the molecular mechanism underlying both the cytoadherence and erythrophagocytosis related with severe malaria is not completely understood. Here, we report that the pRBCs bind to the class A scavenger receptors, SR-A and MARCO, which is expressed on the surface of the activated phagocytes.
To identify the cytoadherence of pRBCs to SR-A and MARCO, human SR-A or MARCO cDNA was transfected to CHO cells (CHO-SR-A or CHO-MARCO cells). Furthermore, several mutants of both molecules were made to identify the sites related with pRBC adherence. pRBCs adhered to the both CHO- SR-A and CHO-MARCO cells, but not to the CHO-mock cells. The pRBC did not observed adherence to the deletion mutants of SRCR domain in both scavenger receptors.
These results may suggest that both SR-A and MARCO acts as a host factor related with cytoadherence of the pRBCs, and contribute to our present understanding the pathology of severe falciparum malaria.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 2008

All Presentation (11 results)

  • [Presentation] Scavenger receptor-Aは分子内 cystein-rich 領域で熱帯熱マラリア原虫感染赤血球を認織する2010

    • Author(s)
      畑生俊光、嶋田淳子
    • Organizer
      第8回沖縄フォーラム
    • Place of Presentation
      カルチャーリゾートフェストーネ、沖縄
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] スカベンジャーレセプターMARCOは分子内SRCR domain でマラリア感染赤血球と接着する2010

    • Author(s)
      雨宮健司、畑生俊光、嶋田淳子
    • Organizer
      第8回沖縄フォーラム
    • Place of Presentation
      カルチャーリゾートフェストーネ、沖縄
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Scavenger receptor-Aは分子内cysteine-rich領域で熱帯熱マラリア原虫感染赤血球を認識する2010

    • Author(s)
      畑生俊光、嶋田淳子
    • Organizer
      第8回沖縄フォーラム
    • Place of Presentation
      宜野湾市、沖縄
    • Year and Date
      2010-02-11
    • Related Report
      2009 Final Research Report
  • [Presentation] スカベンジャーレセプターMARCOは分子内SRCR domainでマラリア感染赤血球と接着する2010

    • Author(s)
      雨宮健司、畑生俊光、嶋田淳子
    • Organizer
      第8回沖縄フォーラム
    • Place of Presentation
      宜野湾市, 沖縄
    • Related Report
      2009 Final Research Report
  • [Presentation] Scavenger receptor-Aは分子内cystein-rich領域で熱帯熱マラリア原虫感染赤血球を認識する2009

    • Author(s)
      畑生俊光、嶋田淳子
    • Organizer
      分子寄生虫マラリアフォーラム
    • Place of Presentation
      千里ライフサイエンスセンター、大阪
    • Year and Date
      2009-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Scavenger receptor-Aは分子内 cystein-rich 領域で熱帯熱マラリア原虫感染赤血球を認識する2009

    • Author(s)
      畑生俊光、嶋田淳子
    • Organizer
      分子寄生虫マラリアフォーラム
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2009-10-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規細胞接着因子としてのScavenger Receptor with C type Lectin(SRCL)の同定2009

    • Author(s)
      畑生俊光、狩野繁之、嶋田淳子
    • Organizer
      第78回日本寄生虫学会
    • Place of Presentation
      法政大学外堀校舎、東京
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] CXCL16/SR-PSOX, membrane-bound form chemokine/a member of scavenger receptor, acts as a receptor of both the cvtoadherence and ervthrophagocvtosis in severe malaria2009

    • Author(s)
      Toshimitsu Hatabu, Shigeyuki Kano, Junko Nakaiima-Shimada
    • Organizer
      43^<rd> Annual U.S.-Japan Joint Conference on Parasitic Diseases
    • Place of Presentation
      函立国際医療センター、東京
    • Year and Date
      2009-01-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] SR-PSOX/CXCL16, scavenger receptor/ membrane-bound form chemokine, is a cytoadherence-related molecule to Plasmodium falcioarum-infected erythrocytes2008

    • Author(s)
      Toshimitsu Hatabu, Shigeyuki Kano, Junko Nakaiima-Shimada
    • Organizer
      XVIIth International Congress of Tropical Medicine and Malaria
    • Place of Presentation
      チェジュ島、大韓民国
    • Related Report
      2008 Annual Research Report
  • [Presentation] スカベンジャーレセプターはマラリア重症化にどのような役割を果たしているのか?2008

    • Author(s)
      畑生俊光
    • Organizer
      第16回分子寄生虫学ワークショップ
    • Place of Presentation
      草津セミナーハウス、群馬
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規細胞接着因子としてのスカベンジャーレセプターAの解析2008

    • Author(s)
      畑生俊光、狩野繁之、嶋田淳子
    • Organizer
      第77回日本寄生虫学会
    • Place of Presentation
      長崎パブリックホール、長崎
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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