Analysis of host cell cycle arrest mechanism by EPEC infection
| Project/Area Number |
20790330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KIM Minsoo The University of Tokyo, 医科学研究所, 特任助教 (50466835)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 感染免疫 / 細胞周期 / 病原性大腸菌 |
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| Research Abstract |
EPEC infection causes host cell cycle arrest. We found that Cif (cell cycle inhibiting factors) secreted by EPEC on bacterial infection inhibited host cell cycle progression at G1 Phase by interacting with host cell factor. Our study suggested that EPEC deploys a special tactic to prevent rapid epithelial turnover in order to maintain epithelial cells.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Listeria monocytogenes ActA-mediated escape from autophagic recognition2009
Author(s)
Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim Minsoo, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C
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Journal Title
Nature Cell biology 11(19)
Pages: 1233-1240
Related Report
Peer Reviewed
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