Investigation of the cytolytic mechanisms of Panton-Valentine leukocidin
| Project/Area Number |
20790331
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Niigata University |
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Principal Investigator |
NISHIYAMA Akihito Niigata University, 医歯学系, 助教 (80452069)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 病原性 / 市中感染型MRSA / 深部感染 / Panton-Valentineロイコシジン / 毒素活性 / 細菌 / 感染症 / 市中感型MRSA |
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| Research Abstract |
Panton-Valentine leukocidin (PVL) is a virulence factor of community-acquired methicillin-resistant Staphylococcus aureus. We have demonstrated the lipid raft-mediated pore formation of PVL. Since integrity of lipid rafts did not affect on the recognition of target cells by PVL, novel PVL receptor(s), other than ganglioside GM1, is suggested. This receptor molecule may be a possible target of PVL inhibitor.
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Emergence of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone in a Japanese child, demonstrating multiple divergent strains in Japan2010
Author(s)
Higuchi W, Mimura S, Kurosawa Y, Takano T, Iwao Y, Yabe S, Razvina O, Nishiyama A, Ikeda-Dantsuji Y, Sakai F, Hanaki H, Yamamoto T
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Journal Title
J. Infect. Chemother (In press)
NAID
Related Report
Peer Reviewed
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[Journal Article] A rapidscreening method for Panton-Valentineleucocidin-positive community-acquiredmethicillin-resistant Staphylococcus aureusbelonging to multilocus sequence type 30 andits related clone using a combination ofmultiplex PCR and pulsed-field gelelectrophoresis.2009
Author(s)
Reva I, Higuchi W, Takano T, Singur O, Ozaki K, Isobe H, Yabe S, Saito K, Baranovich T, Enany S, Otsuka T, Potapov V, Nishiyama A, Yamamoto T
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Journal Title
J. Infect. Chemother 15
Pages: 75-83
Related Report
Peer Reviewed
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[Presentation] Types of the cagA gene sequence, especially its tyrosine phosphorylation motif, of Helicobacter pylori strains from Russia2009
Author(s)
Higuchi W, Takano T, Nishiyama A, Reva I, Potapov V, Yamamoto T
Organizer
Abstract (P-136) presented at 15th International Workshop on Campylobacter, Helicobacter, and Related Organisms (CHRO2009)
Place of Presentation
Niigata, Japan
Year and Date
2009-09-04
Related Report
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[Presentation] Molecular epidermiology of Helicobacter pylori isolated from Russia2009
Author(s)
Reva I, Pererva O, Yabe S, Iwao Y, Higuchi W, Takano T, Nishiyama A, Taneike I, Nakagawa S, Potapov V, Yamamoto T
Organizer
Abstract (O11-5) presented at 15th International Workshop on Campylobacter, Helicobacter, and Related Organisms (CHRO2009)
Place of Presentation
Niigata, Japan
Year and Date
2009-09-04
Related Report
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