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Functional analysis of novel protein secretion system, T6SS in Vibrio parahaemolyticus

Research Project

Project/Area Number 20790335
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bacteriology (including Mycology)
Research InstitutionOsaka University

Principal Investigator

AKEDA Yukihro  Osaka University, 微生物病研究所, 特任講師 (60444527)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords腸炎ビブリオ / タンパク質分泌機構 / 6型タンパク質分泌装置
Research Abstract

There are various protein secretion systems in pathogenic gram-negative bacteria. Recently, a novel protein secretion system, T6SS, has been reported. In this project, it has been found that V. parahaemolyticus has a T6SS. which can secrete and translocate a novel protein in T6SS-dependent manner. This protein secretion requires N-terminal region of a novel secreted protein.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2010 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 9 results) Presentation (10 results)

  • [Journal Article] Tetsuya Iida and Takeshi Honda. Aeromonas hydrophila PepO outer membrane endopeptidase activates human big endothelin-3 in vitro and induces skin ulcer in goldfish (Carassius auratus)2010

    • Author(s)
      Said Kamal Abolghait, Yukihiro Akeda, Toshio Kodama, Vlademir V. Cantarelli
    • Journal Title

      Veterinary Microbiology (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two regulators of Vibrio parahaemolyticus play important roles in enterotoxicity by controlling the expression of genes in the Vp-PAI region2010

    • Author(s)
      Toshio Kodama, Kazuyoshi Gotoh, Hirotaka Hiyoshi, Mikiharu Morita, Kaori Izutsu, Yukihiro Akeda, Kwon-Sam Park, Vlademir Cantarelli, Rikard Dryselius, Tetsuya Iida, Takeshi Honda
    • Journal Title

      PLoS ONE 5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two regulators of Vibrio parahaemolyticus play important roles in enter otoxicity by controlling the expression of genes in the Vp-PAI region.2010

    • Author(s)
      T Kodama, K Gotoh, H Hiyoshi, M Morita, K Izutsu, Y Akeda, KS Park, V Cantarelli, R Dryselius, T lida, T Honda
    • Journal Title

      PLoS ONE 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a type III secretion-associated chaperone in the type III secretion system 1 of Vibrio parahaemolyticus2009

    • Author(s)
      Yukihiro Akeda, Kanna Okayama, Tomomi Kimura, Rikard Dryselius, Toshio Kodama, Kazunori Oishi, Tetsuya Iida, Takeshi Honda
    • Journal Title

      FEMS Microbiology Letters 296

      Pages: 18-25

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intranasal immunization with a mixture of PspA and a Toll-like receptor agonist induces specific antibodies and enhances bacterial clearance in the airways of mice2009

    • Author(s)
      Keita Oma, Jizi Zhao, Hirokazu Ezoe, Yukihiro Akeda, Shohei Koyama, Ken J. Ishii, Kosuke Kataoka, Kazunori Oishi
    • Journal Title

      Vaccine 27

      Pages: 3181-3188

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a type III secretion-associated chaperone in the type III secretion system 1 of Vibrio parahaemolyticus2009

    • Author(s)
      Y Akeda, K Okayama, T Kimura, R Dryselius, T Kodama, K Oishi, T Iida, T Honda
    • Journal Title

      FEMS Microbiology Letters 296

      Pages: 18-25

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intranasal immunization with a mixture of PspA and a Toll-like receptor agonist induces specific antibodies and enhances bacterial clearance in the airways of mice2009

    • Author(s)
      K Oma, J Zhao, H Ezoe, Y Akeda, S Koyama, KJ Ishii, K Kataoka, K Oishi.
    • Journal Title

      Vaccine 27

      Pages: 3181-3188

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sixty years of Vibrio parahaemolyticus research2008

    • Author(s)
      Takeshi Honda, Tetsuya Iida, Yukihiro Akeda, Toshio Kodama
    • Journal Title

      Microbe 3

      Pages: 462-466

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of two translocon proteins of Vibrio parahaemolyticus type III secretion system 22008

    • Author(s)
      Toshio Kodama, Hirotaka Hiyoshi, Kazuyoshi Goto, h, Yukihiro Akeda, Shigeaki Matsuda, Kwon-Sam Park, Vlademir V. Cantarelli, Tetsuya Iida, Takeshi Honda
    • Journal Title

      Infection and Immunity 76

      Pages: 4282-4289

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腸管出血性大腸菌O157感染症2008

    • Author(s)
      明田幸宏
    • Journal Title

      綜合臨床 57

      Pages: 693-2696

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Journal Article] Identification of two translocon proteins of Vibrio parahaemolyticus type III secretion system 22008

    • Author(s)
      T Kodama, H Hiyoshi, K Gotoh, Y Akeda, S Matsuda, KS Park, VV Cantarelli, T Iida, T Honda
    • Journal Title

      Infection and Immunity 76

      Pages: 4282-4289

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sixty years of Vibrio parahaemolyticus research2008

    • Author(s)
      T Honda, T Iida, Y Akeda, T Kodama
    • Journal Title

      Microbe 3

      Pages: 462-466

    • Related Report
      2008 Annual Research Report
  • [Presentation] Protein secretion systems of Vibrio parahaemolyticus2010

    • Author(s)
      明田幸宏
    • Organizer
      第84回日本細菌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Protection of fatal secondary pneumococcal infection following influenza virus infection by pneumococcal surface protein A (PspA) immunization2010

    • Author(s)
      Hirokazu Ezoe, Yukihihiro Akeda, Kazunori Oishi
    • Organizer
      US-Japan Cooperative Medical Science Program Acute Respiratory Infections Panel 2010
    • Place of Presentation
      San Francisco, CA USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Protection of fatal secondary pneumococcal infection following influenza virus infection by pneumococcal surface protein A (PspA) immunization2010

    • Author(s)
      Hirokazu Ezoe, Yukihiro Akeda, Kazunori Oishi
    • Organizer
      US-Japan Cooperative Medical Science Program-Acute Respiratory Infections Panel
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protein secretion systems of Vibrio parabaemolyticus2010

    • Author(s)
      明田幸宏
    • Organizer
      第83日本細胞学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス致死的肺炎モデルを場とした低用量のPspAとTLR ligand併用による経鼻粘膜ワクチンの効果2009

    • Author(s)
      朴貞玉、江副浩和、大間敬太、明田幸宏、大石和徳
    • Organizer
      第52回日本感染症学会中日本地方会学術集会・第57回日本化学療法学会西日本支部総会合同集会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] タイで急増するヒトStreptococcus suis感染症の分子疫学的検討2009

    • Author(s)
      大石和徳、内田隆一、明田幸宏
    • Organizer
      第83回日本感染症学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] マウス肺炎モデルを場としたPspAに対するTLR ligandの粘膜アジュバント効果2009

    • Author(s)
      江副浩和、大間敬太、明田幸宏、大石和徳
    • Organizer
      第83回日本感染症学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 腸炎ビブリオT3SS2シャペロンの同定とその機能解析2009

    • Author(s)
      明田幸宏、児玉年央、大石和徳、飯田哲也、本田武司
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] マウス肺炎モデルを場としたPspAに対するTLR ligandの粘膜アジュバント効果2009

    • Author(s)
      江副浩和、大間敬太、明田幸宏、大石和徳
    • Organizer
      第83回日本感染症学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス致死的肺炎モデルを場とした低用量のPspAとTLR ligand併用による経鼻粘膜ワクチンの効果2009

    • Author(s)
      朴貞玉、江副浩和、大間敬太、明田幸宏、大石和徳
    • Organizer
      第52回日本感染症学会中日本地方会学術集会・第57会日本化学療法学会西日本支部総会 合同集会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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