| Project/Area Number |
20790337
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Okayama University |
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Principal Investigator |
KURODA Teruo Okayama University, 大学院・医歯薬学総合研究科, 准教授 (80304327)
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| Research Collaborator |
NAKAMURA Koji 岡山大学, 大学院・医歯薬学総合研究科, 博士後期課程
TANI Kiyohito 岡山大学, 大学院・医歯薬学総合研究科, 博士前期課程
MURAI Michiko 岡山大学, 大学院・医歯薬学総合研究科, 博士前期課程
NAGIRA Yu 岡山大学, 大学院・医歯薬学総合研究科, 博士前期課程
SHIRAISHI Naoko 岡山大学, 薬学部・薬学科
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Na^+ / H^+アンチポーター / 呼吸鎖Na^+ポンプ / 腸炎ビブリオ / 多剤排出ポンプ / 胆汁酸 |
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| Research Abstract |
We analyzed the environmental adaptation mechanisms in Vibrios. In Vibrio parahaemolyticus, respiratory Na+ pump as well as Na+/H+ antiporters plays an important role for Na+ extrusion from the cells. Multidrug efflux pumps are essential for the resistance for bile acids and antimicrobial agents, and we identified seven new pumps in V. parahaemolyticus. The mutant which lacked 14 multidrug efflux pump genes showed hyper sensitivity to bile acids and antimicrobial agents. It was also suggested the mutant showed lower pathogenicity in rabbit intestinal tract.
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