Identification and characterization of a new DNA double strand break repair pathway in enterohemorrhagic Escherichia coli
| Project/Area Number |
20790338
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of Miyazaki |
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Principal Investigator |
OOKA Tadasuke University of Miyazaki, 医学部, 助教 (50363594)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 微生物 / 細菌 / ゲノム / 遺伝子 |
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| Research Abstract |
We identified a new factor that promote the excision of insertion sequence element (IS) in enterohemorrhagic Escherichia coli, and named the protein as IS-excision enhancer (IEE). From the functional analyses, IEE promote the excision of IS3 members from the Escherichia coli O157 genome by combined action with IS transposase. In addition, homologs of IEE were widely distributed in a variety of bacterial species by horizontal gene transfer.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Development of a multiplex PCR-based rapid typing method 1 for enterohemorrhagic Escherichia coli O157 strains2009
Author(s)
T. Ooka, J. Terajima, M. Kusumoto, A. Iguchi, K. Kurokawa, Y. Ogura, M. Asadulghani, K. Nakayama, K. Murase, M. Ohnishi, S. Iyoda, H. Watanabe, T. Hayashi
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Journal Title
J. Clin. Microbiol 47(9)
Pages: 2888-2894
Related Report
Peer Reviewed
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[Journal Article] Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli2009
Author(s)
Y. Ogura, T. Ooka, A. Iguchi, H. Toh, Md. Asadulghani, K. Oshima, T. Kodama, H. Abe, K. Nakayama, K. Kurokawa, T. Tobe, M. Hattori, T. Hayashi
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Journal Title
Proc. Natl. Acad. Sci. USA 106(42)
Pages: 17939-17944
Related Report
Peer Reviewed
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[Journal Article] The complete genome sequence and comparative genome analysis of enteropathogenic E.coli O127:H6 strain E2348/692009
Author(s)
A. Iguchi, N.R. Thomson, Y. Ogura, D. Saunders, T. Ooka, I.R. Henderson, D. Harris, Asadulghani, K. Kurokawa, P. Dean, B. Kenny, M.A. Quail, S. Thurston, G. Dougan, T. Hayashi, J. Parkhill, *G. Frankel
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Journal Title
J. Bacteriol. 191(1)
Pages: 347-354
Related Report
Peer Reviewed
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[Journal Article] Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult2008
Author(s)
K. Oshima, H. Toh, Y. Ogura, H. Sasamoto, H. Morita, S. -H. Park, T. Ooka, S. Iyoda, T.D. Taylor, T. Hayashi, K. Itoh, M. Hattori
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Journal Title
DNA Res 15(6)
Pages: 375-386
Related Report
Peer Reviewed
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[Journal Article] Systematic identification and sequence analysis of the genomic islands of the enteropathogenic Escherichia coli strain B171-8 by the combined use of Whole Genome PCR Scanning and fosmid mapping2008
Author(s)
Y. Ogura, H. Abe, K. Katsura, K. Kurokawa, Asadulghani, A. Iguchi, T. Ooka, K. Nakayama, A. Yamashita, M. Hattori, T. Tobe, T. Hayashi
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Journal Title
J. Bacteriol 190(21)
Pages: 6948-6960
Related Report
Peer Reviewed
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[Journal Article] The whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution.2008
Author(s)
K. Nakayama, A. Yamashita, K. Kurokawa, T. Morimoto, M. Ogawa, M. Fukuhara, H. Urakami, M. Ohnishi, I. Uchiyama, Y. Ogura, T. Ooka, K. Oshima, A. Tamura, M. Hattori, T. Hayashi
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Journal Title
DNA Res. 15
Pages: 185-199
Related Report
Peer Reviewed
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