| Project/Area Number |
20790341
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Juntendo University |
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Principal Investigator |
MURAKAMI Taisuke Juntendo University, 医学部, 助教 (40384135)
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| Co-Investigator(Renkei-kenkyūsha) |
OBATA Toru 東京慈恵会医科大学, DNA 医学研究所, 准教授 (80119776)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 感染免疫 / 敗血症性ショック / resolvin / HMGB1 / エンドトキシン / レゾルビン / リポ多糖(LPS) |
|---|
| Research Abstract |
Resolvins are a family of potent anti-inflammatory lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. However, it has been unclear whether RvD1 exhibits protective action in endotoxic shock. In this study, to elucidate the effect of RvD1 on septic shock, we investigated the effect of RvD1 on inflammatory mediators, using D-galactosamine-primed endotoxin shock model.
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