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Functional analysis of Toll-like receptor 10

Research Project

Project/Area Number 20790342
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bacteriology (including Mycology)
Research InstitutionKurume University

Principal Investigator

SHIMIZU Takashi  Kurume University, 医学部, 助教 (40320155)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords感染免疫 / Toll-like receptor(TLR) / リポプロテイン / マイコプラズマ / Helicobacter pyroli / Toll-like RecePtor
Research Abstract

TLR10 expression in 293T cells suppressed the activation of NF-κB by lipoproteins through TLR2. This result indicates that TLR10 plays an important role to inhibit and control the inflammatory responses induced by TLR2.
We examined the relationship between TLR10 and TLR2 independent inflammatory responses induced by cytoadherence of Mycoplasma pneumoniae. The induction of TLR2 independent inflammatory responses by cytoadherence of M. pneumonia was dependent of ATP and P2X7 receptor, but independent of TLR10.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (24 results)

All 2011 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (22 results)

  • [Journal Article] Cytoadherence-dependent induction of inflammatory responses by Mycoplasma pneumoniae.2011

    • Author(s)
      Shimizu T, Kida Y, Kuwano K
    • Journal Title

      Immunology. in press

    • NAID

      10030541589

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cytoadherence-dependent induction of inflammatory responses by Mycoplasma pneumoniae2011

    • Author(s)
      Shimizu Takashi, Kida Yutaka, Kuwano Koichi
    • Journal Title

      Immunology

      Volume: (in press)

    • NAID

      10030541589

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mycoplasma pneumoniaeの接着に依存的な炎症誘導2010

    • Author(s)
      清水隆、木田豊、桑野剛一
    • Organizer
      第63回細菌学会九州支部総会
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Mycoplasma pneumoniaeの接着に依存的な炎症誘導2010

    • Author(s)
      清水隆
    • Organizer
      第63回細菌学会九州支部総会
    • Place of Presentation
      ホテルメリージュ/宮崎県
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Helicobacter pyliriの炎症誘導リポプロテインの同定2010

    • Author(s)
      清水隆、三室仁美
    • Organizer
      第5回細菌学・若手コロッセウム
    • Year and Date
      2010-08-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Helicobacter pyliriの炎症誘導リポプロテインの同定2010

    • Author(s)
      清水隆
    • Organizer
      第5回細菌学・若手コロッセウム
    • Place of Presentation
      ラフォーレ修善寺/静岡県
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cytoadherence-dependent Induction of Inflammatory Responses by Mycoplasma pneumoniae2010

    • Author(s)
      Shimizu T, Kida Y, Kuwano K
    • Organizer
      第18回国際マイコプラズマ学会
    • Year and Date
      2010-07-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Cytoadherence-dependent Induction of Inflammatory Responses by ycoplasma pneumoniae2010

    • Author(s)
      清水隆
    • Organizer
      第18回国際マイコプラズマ学会
    • Place of Presentation
      キャンチアーノ・テルメ/イタリア
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mycoplasma pneumoniaeの接着に依存的な炎症誘導2010

    • Author(s)
      清水隆、木田豊、桑野剛一
    • Organizer
      第37回日本マイコプラズマ学会
    • Year and Date
      2010-06-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Mycoplasma pneumoniaeの接着に依存的な炎症誘導2010

    • Author(s)
      清水隆
    • Organizer
      第37回日本マイコプラズマ学会
    • Place of Presentation
      国立感染症研究所/東京
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mycoplasma pneumoniaeの接着に依存的な炎症誘導2010

    • Author(s)
      清水隆、木田豊、桑野剛一
    • Organizer
      第83回日本細菌学会総会
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Mycoplasma pneumoniae の接着に依存的な炎症誘導2010

    • Author(s)
      清水隆
    • Organizer
      日本細菌学会総会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inflammation-inducing lipoproteins of pathogenic mycoplasmas2009

    • Author(s)
      Shimizu T, Kida Y, Kuwano K
    • Organizer
      第4回アジアマイコプラズマ学会
    • Year and Date
      2009-11-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Inflammation-inducing lipoproteins of pathogenic mycoplasmas2009

    • Author(s)
      清水隆
    • Organizer
      アジアマイコプラズマ学会
    • Place of Presentation
      Animal Health Research Institute, Danshui, Taiwan
    • Year and Date
      2009-11-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mycoplasma pneumoniaeの接着に依存的な炎症誘導2009

    • Author(s)
      清水隆、木田豊、桑野剛一
    • Organizer
      第4回細菌学・若手コロッセウム
    • Year and Date
      2009-10-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 炎症を誘導する病原性マイコプラズマのリポプロテイン2009

    • Author(s)
      清水隆、木田豊、桑野剛一
    • Organizer
      第62回細菌学会九州支部総会
    • Year and Date
      2009-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 炎症を誘導する病原性マイコプラズマのリポプロテイン2009

    • Author(s)
      清水隆
    • Organizer
      日本細菌学会九州支部総会
    • Place of Presentation
      佐賀大学
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 接着に依存的なMycoplasma pneumoniaeの炎症誘導2009

    • Author(s)
      清水隆、木田豊、桑野剛一
    • Organizer
      第36回日本マイコプラズマ学会
    • Year and Date
      2009-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 接着に依存的なM.pneumoniae の炎症誘導2009

    • Author(s)
      清水隆
    • Organizer
      日本マイコプラズマ学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mycoplasma genitalium由来リポタンパク質によるToll-like receptorシグナルの活性化2009

    • Author(s)
      清水隆、木田豊、桑野剛一
    • Organizer
      第82回日本細菌学会総会
    • Related Report
      2010 Final Research Report
  • [Presentation] Inflammation-inducing lipoproteins of Mycoplasma pneumoniae2008

    • Author(s)
      Shimizu T, Kida Y, Kuwano K
    • Organizer
      第9回日韓微生物シンポジウム
    • Year and Date
      2008-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Inflammation-inducing lipoproteins of Mycoplasma pneumoniae2008

    • Author(s)
      Shimizu T, Kida Y, Kuwano K
    • Organizer
      第17回国際マイコプラズマ学会
    • Year and Date
      2008-07-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Inflammation-Inducing Lipoproteins of Mycoplasma pneumoniae2008

    • Author(s)
      清水隆
    • Organizer
      国際マイコプラズマ学会
    • Place of Presentation
      中国、天津
    • Year and Date
      2008-07-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ureaplasma parvum由来リポタンパク質によるToll-like receptorシグナルの活性化2008

    • Author(s)
      清水隆、木田豊、桑野剛一
    • Organizer
      第35回日本マイコプラズマ学会
    • Year and Date
      2008-05-31
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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