Extensive analysis of human cellular factors that target simian immunodeficiency virus replication
| Project/Area Number |
20790350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKEUCHI Hiroaki The University of Tokyo, 医科学研究所, 特任助教 (20451867)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 感染防御 / ワクチン / ウイルス / エイズ / 感染症 / 異種間感染 / 人畜共通感染症 / 細胞内免疫 |
|---|
| Research Abstract |
An understanding of host cell factors that affect viral replication contributes to elucidation of the mechanism for determination of viral tropism. SIV infection was not significantly affected by knock-down of CypA, an essential factor for HIV-1 replication, but enhanced by knock-down of CypB, another PPIase, in human target cells. These results imply different effects of CypA/CypB on HIV-1 and SIV replication.
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Report
(3 results)
Research Products
(21 results)
