Extensive analysis of human cellular factors that target simian immunodeficiency virus replication

• Project/Area Number: 20790350
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Virology
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEUCHI Hiroaki The University of Tokyo, 医科学研究所, 特任助教 (20451867)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 感染防御 / ワクチン / ウイルス / エイズ / 感染症 / 異種間感染 / 人畜共通感染症 / 細胞内免疫

Research Abstract

An understanding of host cell factors that affect viral replication contributes to elucidation of the mechanism for determination of viral tropism. SIV infection was not significantly affected by knock-down of CypA, an essential factor for HIV-1 replication, but enhanced by knock-down of CypB, another PPIase, in human target cells. These results imply different effects of CypA/CypB on HIV-1 and SIV replication.

Research Products

• [Journal Article] Contribution of Cyclophilin A to determination of simian immunodeficiency virus tropism: A progress update. (2010)
  • Author(s): Takeuchi H.
  • Journal Title: Vaccine. 28Suppl2 Pages: 51-4
  • Peer Reviewed
• [Journal Article] Contribution of Cyclophilin A to determination of simian immunodeficiency virus tropism : A progress update (2010)
  • Author(s): Hiroaki Takeuchi
  • Journal Title: Vaccine (印刷中)
  • Peer Reviewed
• [Journal Article] エイズウイルスの異種間感染メカニズム (2009)
  • Author(s): 武内寛明
  • Journal Title: The Journal of AIDS Research 11(2) Pages: 104-105
• [Journal Article] Host factors involved in resistance to retroviral infection. (2008)
  • Author(s): Takeuchi H, Matano T.
  • Journal Title: Microbiol Immunol. 52(6) Pages: 318-25
  • NAID: 40016123018
  • Peer Reviewed
• [Journal Article] Gag-specific cytotoxic T-lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial. (2008)
  • Author(s): Kawada M, Tsukamoto T, Yamamoto H, Iwamoto N, Kurihara K, Takeda A, Moriya C, Takeuchi H, Akari H, Matano T.
  • Journal Title: J Virol. 82(20) Pages: 10199-206
  • Peer Reviewed
• [Presentation] Cyclophilinsはエイズウイルストロピズムを規定する細胞内因子である。 (2009)
  • Author(s): 武内寛明、石井洋、俣野哲朗
  • Organizer: 第23回日本エイズ学会学術集会・総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-11-28
• [Presentation] Cyclophilins はエイズウイルストロピズムを規定する細胞内因子である (2009)
  • Author(s): 武内寛明
  • Organizer: 第23回日本エイズ学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-11-28
• [Presentation] エイズウイルストロピズムにおけるCyclophilinsの役割 (2009)
  • Author(s): 武内寛明、石井洋、俣野哲朗
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル、東京
  • Year and Date: 2009-10-26
• [Presentation] エイズウイルストロピズムにおける Cyclophilins の役割 (2009)
  • Author(s): 武内寛明
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル、東京
  • Year and Date: 2009-10-25
• [Presentation] Species-specific Effect of Cyclosporine A on Simian Immunodeficiency Virus Replication: Possible Contribution of Cyclophilins to the Determination of Viral Tropism. (2009)
  • Author(s): Takeuchi H.
  • Organizer: China-Japan Research Collaboration on Emerging and Reemerging Infections
  • Place of Presentation: Beijing, China
  • Year and Date: 2009-10-22
• [Presentation] Species-specific effect of cyclosporine A on simian immunodeficiency virus replication: possible contribution of cyclophilins to the determination of viral tropism. (2009)
  • Author(s): Takeuchi H, Ishii H, Matano T
  • Organizer: The 9th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji Island, Japan
  • Year and Date: 2009-09-10
• [Presentation] Species-specific effect of cyclosporine A on simian immunodeficiency virus replication : possible contribution of cyclophilins to the determination of viral tropism (2009)
  • Author(s): 武内寛明
  • Organizer: The 9^<th> Awaji International Forum on Infection and Immunity
  • Place of Presentation: 兵庫県立淡路夢舞台国際会議場
  • Year and Date: 2009-09-10
• [Presentation] Cyclophilin B has an inhibitory effect on SIV but not HIV-1 replication in human cells. (2009)
  • Author(s): Takeuchi H, Ishii H, Matano T.
  • Organizer: Cold Spring Habor Laboratory Meeting on Reroviruses
  • Place of Presentation: New York, USA
  • Year and Date: 2009-05-19
• [Presentation] Cyclophilin B has an inhibitory effect on SIV but not HIV-1 replication in human cells (2009)
  • Author(s): 武内寛明
  • Organizer: Cold Spring Habor Laboratory Meeting on Reroviruses
  • Place of Presentation: New York, USA
  • Year and Date: 2009-05-19
• [Presentation] エイズウイルスの異種間感染メカニズム～新興・再興感染症に対する新規治療および予防法の確立に向けて～ (2008)
  • Author(s): 武内寛明
  • Organizer: 第22回日本エイズ学会学術集会・総会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2008-11-27
• [Presentation] エイズウイルスの異種間感染メカニズム-新興・再興感染症に対する新規治療および予防法の確立に向けて- (2008)
  • Author(s): 武内寛明
  • Organizer: 第22回日本エイズ学会学術集会・総会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2008-11-27
• [Presentation] Cyclophilin Aはサルエイズウイルスの宿主域を規定する細胞内因子である。 (2008)
  • Author(s): 武内寛明、石井洋、桑野哲矢、稲垣奈都子、明里宏文、俣野哲朗
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2008-10-27
• [Presentation] Cyclophilin Aはサルエイズウイルスの宿主域を規定する細胞内因子である (2008)
  • Author(s): 武内寛明
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2008-10-27
• [Presentation] Contribution of cyclophilin A to determination of simian immunodeficiency virus tropism. (2008)
  • Author(s): H. Takeuchi, H. Ishii, T. Kuwano, N. Inagaki, H. Akari, T. Matano
  • Organizer: The 8th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji Island, Japan
  • Year and Date: 2008-09-10
• [Presentation] Contribution of cyclophilin A to determination of simian immunodeficiency virus tropism (2008)
  • Author(s): Hiroaki Takeuchi
  • Organizer: The 8^<th> Awaji International Forum on Infection and Immunity
  • Place of Presentation: 兵庫県立淡路夢舞台国際会議場
  • Year and Date: 2008-09-10
• [Presentation] Cyclophilin A affects SIV replication positively in monkey but negatively in human cells. (2008)
  • Author(s): H. Takeuchi, N. Inagaki, H. Ishii, T. Kuwano, H. Akari, T. Matano
  • Organizer: Cold Spring Habor Laboratory Meeting on Reroviruses
  • Place of Presentation: New York, USA
  • Year and Date: 2008-05-20