Analysis of long untranslated regions in Nipah virus genome

• Project/Area Number: 20790351
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Virology
• Research Institution: The University of Tokyo
• Principal Investigator: SATO Hiroki The University of Tokyo, 医科学研究所, 助教 (50418654)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 病原性 / ニパウイルス / 非翻訳領域

Research Abstract

To reveal the importance of long untranslated regions in Nipah virus mRNAs, comparative analysis of gene expression efficiency using a dicistronic minigenome assay system was conducted. It was revealed that upstream gene shows higher transcription efficiency than downstream genes.

Research Products

• [Journal Article] Measles virus induced cell-type specific changes in gene expression. (2008)
  • Author(s): Sato, H., Honma, R., Yoneda, M., Miura, R., Tsukiyama-Kohara, K., Ikeda, F., Seki, T., Watanabe, S., Kai, C.
  • Journal Title: Virology Pages: 321-330
• [Journal Article] Measles virus induced cell-type specific changes in gene expression (2008)
  • Author(s): Sato, H.
  • Journal Title: Virology 375 Pages: 321-330
  • Peer Reviewed
• [Presentation] Analysis of comprehensive downregulation of housekeeping genes triggered by morbillivirus infection
  • Organizer: 第32回日本分子生物学会
• [Presentation] モービリウイルスアクセサリーC蛋白による宿主遺伝子群発現維持機構の解明
  • Organizer: 第56回日本ウイルス学会
• [Book] ジステンパーウイルス(特集:動物のウイルス感染症)(Virus Report,6) (2009)
  • Author(s): 佐藤宏樹、甲斐知恵子