| Project/Area Number |
20790356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
OKABAYASHI Tamaki Sapporo Medical University, 医学部, 講師 (10359995)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 病原性 / RSウイルス / ホスホマシン / RANTES / NF-κB / サイトカイン |
|---|
| Research Abstract |
Respiratory syncytial virus (RSV) is one of the most common causes of respiratory diseases in children. Nasal epithelial cell (NEC) is the first site exposure to RSV. NEC induced type-III IFN by RSV infection, but not merely type-I IFN. Our results showed that RIG-I, one of the virus sensors, contributed to this type-III IFN production. Fosfomycin, anti-bacterial agent, suppressed the RSV-induced a proinflammatory chemokine, RANTES production, and a receptor for Streptococcus pneumoniae, platelet-activating factor receptor expression, by inhibition of transcription factor NF-κB activity.
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