Functional glycomics of influenza virus-binding asialoglycolipid on virus infection
| Project/Area Number |
20790357
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | University of Shizuoka |
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Principal Investigator |
TAKAHASHI Tadanobu University of Shizuoka, 薬学部, 助教 (20405145)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | インフルエンザウイルス / スルファチド / ヘマグルチニン / ウイルス増殖 / ヌクレオプロテイン / ウイルス産生 / パラインフルエンザウイルス |
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| Research Abstract |
We demonstrated that sulfatide enhanced influenza A virus (IAV) replication through efficient translocation of the newly synthesized IAV nucleoprotein (NP) from the nucleus to the cytoplasm. Our findings suggest new therapeutic strategies.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Sulfatide Is Required for Efficient Replication of Influenza A Virus.2008
Author(s)
Tadanobu Takahashi, Kouki Murakami, Momoe Nagakura, Hideyuki Kishita, Shinya Watanabe, Koichi Honke, Kiyoshi Ogura, Tadashi Tai, Kazunori Kawasaki, Daisei Miyamoto, Kazuya I.P.J. Hidari, Chao-Tan Guo, Yasuo Suzuki, Takashi Suzuki
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Journal Title
J. Virol. 82
Pages: 5940-5950
URL
Related Report
Peer Reviewed
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