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Reverse genetics for rotavirus and its applications

Research Project

Project/Area Number 20790360
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionFujita Health University

Principal Investigator

KOMOTO Satoshi  Fujita Health University, 医学部, 講師 (60367711)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsロタウイルス / ウイルス工学 / リバースジェネティクス / VP4 / ロタイルス / リバースジェネイクテス / ヘルパウイールス
Research Abstract

Recombinant rotaviruses (RVs) containing a cDNA-derived VP4 genome could be generated by means of reverse genetics system. It is expected that this approach will be valuable for the development of novel RV vaccines and vaccine vectors, as well as for an understanding of the molecular basis of RV pathogenesis.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (15 results)

All 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Generation of recombinant rotavirus with an antigenic mosaic of cross-reactive neutralization epitopes on VP4.2008

    • Author(s)
      Komoto, S., Kugita, M., Sasaki, J., Taniguchi, K.
    • Journal Title

      J. Virol. 82

      Pages: 6753-6757

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of recombinant rotavirus with an antigenic mosaic of cross- reactive neutralization epitopes on VP42008

    • Author(s)
      Satoshi Komoto
    • Journal Title

      Journal of Virology 82

      Pages: 6753-6757

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Proteolytic cleavage at the conserved Arginine-241 of Rotavirus VP4 is not essential for virus replication in cell culture.2009

    • Author(s)
      Komoto, S., Taniguchi, K.
    • Organizer
      The 9th Awaji International Forum on Infection and Immunit
    • Place of Presentation
      Hyogo, Japan
    • Year and Date
      2009-09-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Proteolytic cleavage at the conserved Arginine-241 of Rotavirus VP4 is notessential for virus replication in cell culture2009

    • Author(s)
      Satoshi Komoto
    • Organizer
      The 9th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫)
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] VP4上の交叉反応性中和エピトープの抗原モザイクを有する組換えロタウイルスの作製2008

    • Author(s)
      河本聡志、釘田雅則、油井晶子、佐々木潤、守口匡子、前野芳正、石川球美子、谷口孝喜
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] ロタウイルスの新知見2008

    • Author(s)
      河本聡志
    • Organizer
      第20回ウイルス性下痢症研究会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Generation of recombinant rotavirus with an antigenic mosaic of cross-reactive neutralization epitopes on VP4.2008

    • Author(s)
      Komoto, S., Kugita, M., Yui, A., Sasaki, J., Taniguchi, K.
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Hyogo, Japan
    • Year and Date
      2008-09-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Generation of recombinant rotavirus having an antigenic mosaic of cross-reactive neutralization epitopes on VP4.2008

    • Author(s)
      Komoto, S., Kugita, M., Yui, A., Sasaki, J., Moriguchi, K., Maeno, Y., Taniguchi, K.
    • Organizer
      XIV International Congress of Virology
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2008-08-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Generation of recombinant rotavirus having an antigenic mosaic of cross-reactive neutralization epitopes on VP4.2008

    • Author(s)
      Komoto, S., Kugita, M., Yui, A., Sasaki, J., Taniguchi, K.
    • Organizer
      The 42nd Joint Working Conference on Viral Diseases, The Japan-United States Cooperative Medical Science Program
    • Place of Presentation
      Nagasaki, Japan
    • Year and Date
      2008-05-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Generation of recombinant rotavirus having an antigenic mosaic of cross- reactive neutralization epitopes on VP42008

    • Author(s)
      Satoshi Komoto
    • Organizer
      The 42nd Joint Working Conference on Viral Diseases. The Japan- United States Cooperative Medical Science Program
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-27
    • Related Report
      2008 Annual Research Report
  • [Book] ロタウイルス感染性クローンの開発と病原性解析2009

    • Author(s)
      河本聡志、谷口孝喜
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report
  • [Book] ロタウイルスのリバースジェネティクスとその展望2009

    • Author(s)
      谷口孝喜、河本聡志、佐々木潤、釘田雅則
    • Publisher
      日本ウイルス学会
    • Related Report
      2009 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.fujita-hu.ac.jp/~virology/index.htm

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.fujita-hu.ac.jp/~virology/index.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.fujita-hu.ac.jp/~virology/index.htm

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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