| Project/Area Number |
20790363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | National Institute of Biomedical Innovation |
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Principal Investigator |
SADAOKA Tomohiko National Institute of Biomedical Innovation, 大学院・医学研究科, 助教 (00435893)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 感染症・ウイルス粒子成熟 / 出芽・抗ウイルス薬 / 感染症 / ウイルス / ウイルス粒子成熟 / 抗ウイルス薬 / ウイルス粒子出芽 |
|---|
| Research Abstract |
Varicella-zoster virus (VZV) ORF49 gene encodes the tegument protein in VZ virion and is one of the determinants of the VZV cell tropism in vitro. In this study, it has been identified that ORF49 protein interacts with ORF44 protein, which is essential for the lytic infection of the virus, and functions in the proper transportation of ORF44 protein to the place in which the virion maturation has occurred.
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