| Project/Area Number |
20790364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Hokkaido University |
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Principal Investigator |
OSHIUMI Hiroyuki Hokkaido University, 大学院・医学研究科, 講師 (50379103)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自然免疫 / ウイルス / インターフェロン / 核酸 / C型肝炎 / RIG-I / RNA / 免疫 / ユビキチン / 遺伝病 |
|---|
| Research Abstract |
Human innate immune system protect host from viral infection, such as Hepatitis C virus (HCV) or swein flu, which is very harmful. Many virus genome is encoded on RNA, and thus viral RNA is recognized by human receptor molecules, which induce innate immune responses. It is expected that there are many unknown molecule that involved in innate immune responses against viral infection. We tried to isolate novel molecules that are important for host innate immune responses. We succeed to isolate a novel molecule, which we named Riplet and identify that DDX3, an intracellular RNA helicase, is involved in type I interferon production during viral infection.
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