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Isolation and analysis of novel molecules that recognize viral infection

Research Project

Project/Area Number 20790364
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionHokkaido University

Principal Investigator

OSHIUMI Hiroyuki  Hokkaido University, 大学院・医学研究科, 講師 (50379103)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords自然免疫 / ウイルス / インターフェロン / 核酸 / C型肝炎 / RIG-I / RNA / 免疫 / ユビキチン / 遺伝病
Research Abstract

Human innate immune system protect host from viral infection, such as Hepatitis C virus (HCV) or swein flu, which is very harmful. Many virus genome is encoded on RNA, and thus viral RNA is recognized by human receptor molecules, which induce innate immune responses. It is expected that there are many unknown molecule that involved in innate immune responses against viral infection. We tried to isolate novel molecules that are important for host innate immune responses. We succeed to isolate a novel molecule, which we named Riplet and identify that DDX3, an intracellular RNA helicase, is involved in type I interferon production during viral infection.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (23 results)

All 2010 2009 2008

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (6 results)

  • [Journal Article] DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential.2010

    • Author(s)
      押海裕之以下3名省略
    • Journal Title

      European Journal of Immunology 40巻

      Pages: 940-948

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.2010

    • Author(s)
      笹井美和、立松恵、押海裕之、以下4名省略
    • Journal Title

      Molecular Immunology 47巻

      Pages: 1283-1291

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] DEAD/H BOX 3(DDX3)helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential2010

    • Author(s)
      押海裕之
    • Journal Title

      European Journal of Immunology (In Press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pattern recognition receptors of innate immunity and their application to tumor immunotherapy2010

    • Author(s)
      瀬谷司
    • Journal Title

      Cancer Science 101

      Pages: 313-320

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway2010

    • Author(s)
      笹井美和
    • Journal Title

      Molecular Immunology 47

      Pages: 1283-1291

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.2009

    • Author(s)
      高木宏美、押海裕之以下4名省略
    • Journal Title

      European Journal of Immunology 39巻

      Pages: 3469-3476

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.2009

    • Author(s)
      押海裕之, 他12名省略(13人中3番目)
    • Journal Title

      Plos Genetics 6巻

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitofusin 2 inhibits mitochondrial antiviral signaling.2009

    • Author(s)
      安川開、押海裕之、以下6名省略
    • Journal Title

      Science Signaling 2巻

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Riplet/RNA135, a RING Finger Protein, Ubiquitinates RIG-I to promote Interferon-b induction during the Early Phase of Viral Infection.2009

    • Author(s)
      押海裕之、以下3名省略
    • Journal Title

      JBC 284巻

      Pages: 807-817

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulator of complement activation (RCA) gene cluster in Xenopus tropicails.2009

    • Author(s)
      押海裕之、以下3名省略
    • Journal Title

      Immunogenetics 61巻

      Pages: 371-384

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oligomerized TICAM-1(TRIF)in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction2009

    • Author(s)
      高木宏美
    • Journal Title

      European Journal of Immunology 39

      Pages: 3469-3476

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collaborative action of Brcal and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair2009

    • Author(s)
      中村恭子
    • Journal Title

      Plos Genetics 6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitofusin 2 inhibits mitochondrial antiviral signaling2009

    • Author(s)
      安川開
    • Journal Title

      Science Signaling 2

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Riplet/RNA135, a RING Finger Protein, Ubiquitinates RIG-I to promote Interferon-β induction during the Early Phase of Viral Infection2009

    • Author(s)
      Hiroyuki Oshiumi
    • Journal Title

      Journal of Biological Chemisitry 284

      Pages: 807-817

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses.2008

    • Author(s)
      松尾綾、押海裕之、以下6名省略
    • Journal Title

      Journal of Immunology 181巻

      Pages: 347-385

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses2008

    • Author(s)
      Aya Matsuo
    • Journal Title

      Journal of immunology 181

      Pages: 347-385

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulator of complement activation (RCA)gene cluster in Xenopus tropi cails2008

    • Author(s)
      Hiroyuki Oshiumi
    • Journal Title

      Immunogenetics (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ウイルス感染時のRIG-I分子を介したDDX3ヘリケースによるI型インターフェロン産生シグナルの促進機構とC型肝炎ウイルスコア蛋白質による抑制機構の解明2009

    • Author(s)
      押海裕之
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神奈川県
    • Year and Date
      2009-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] ウイルス感染時のRIG-I分子を介したDDX3ヘリケースによるI型インターフェロン産生シグナルの促進機構とC型肝炎ウイルスコア蛋白質による抑制機構の解明2009

    • Author(s)
      押海裕之
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜国際会議場(神奈川県)
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] DDX3 RNA helicase associates with RIG-I and IPS-1, and Hepatitis C virus core protein blocks the interaction of DDX3 with IPS-1 to suppress the type I interferon production2009

    • Author(s)
      押海裕之
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪府
    • Year and Date
      2009-12-03
    • Related Report
      2009 Final Research Report
  • [Presentation] DDX3 RNA helicase associates with RIG-1 and IPS-1, and Hepatitis C virus core protein blocks the interaction of DDX3 with IPS-1 to suppress the type I interferon production2009

    • Author(s)
      押海裕之
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] RNAヘリケースのDDX3はウイルス感染時のIPS-1分子に依存したI型インターフェロン産生に関与する2008

    • Author(s)
      押海裕之
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都府
    • Year and Date
      2008-12-03
    • Related Report
      2009 Final Research Report
  • [Presentation] RNAヘリケースのDDX3はウイルス感染時のIPS-1分子に依存したI型インターフェロン産生に関与する2008

    • Author(s)
      押海裕之
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都国立京都国際会館
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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