| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In this study, we found that Opn expression is induced both in the lung and lymphoid tissues such as spleen following influenza A virus infection. Although initial immune responses are comparable between Opn-deficient and Opn-intact mice, Opn-deficient mice maintained more virus-specific memory CD8^+T cells at 60 days after infection. So far, we assume that osteopontin modulates the generation of memory CD8^+T cells following influenza A virus infection through presumably regulating IL-12 production by antigen presenting cells.
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