The roles of osteopontin and IL-17 in the protective immune responses against virus infection

• Project/Area Number: 20790365
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Hokkaido University
• Principal Investigator: MORIMOTO Junko Hokkaido University, 遺伝子病制御研究所, 助教 (20451396)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ウイルス / 感染症 / 細胞・組織 / 記憶免疫細胞 / 免疫学

Research Abstract

In this study, we found that Opn expression is induced both in the lung and lymphoid tissues such as spleen following influenza A virus infection. Although initial immune responses are comparable between Opn-deficient and Opn-intact mice, Opn-deficient mice maintained more virus-specific memory CD8^+T cells at 60 days after infection. So far, we assume that osteopontin modulates the generation of memory CD8^+T cells following influenza A virus infection through presumably regulating IL-12 production by antigen presenting cells.

Research Products

• [Journal Article] Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA (2010)
  • Author(s): D.Iwata
  • Journal Title: Exp Eye Res 90 Pages: 41-48
  • Peer Reviewed
• [Journal Article] As a Target Molecule for the Treatment of Inflammatory Diseases. (2009)
  • Author(s): Morimoto J, Kon S, Matsui Y, Uede T. Osteopontin
  • Journal Title: Curr. Drug. Tragets
  • Peer Reviewed
• [Journal Article] Regulatory role of DC-derived osteopontin in systemic allergen sensitization. (2009)
  • Author(s): Kurokawa M, Konno S, Takahashi A, Plunkett B, Rittling SR, Matsui Y, Kon S, Morimoto J, Uede T, Matsukura S, Kokubu F, Adachi M, Nishimura M, Huang SK.
  • Journal Title: Eur. J. Immunol 39(12) Pages: 3323-30
  • Peer Reviewed
• [Journal Article] Accelerated development of aging-associated and instanility-induced osteoarthritis in osteopontin-deficinet mice. (2009)
  • Author(s): Matsui Y, Iwasaki N, Kon S, Takahashi D, Morimoto J, Matsui Y, Denhardt DT, Ritting S, Minami A, Uede T.
  • Journal Title: Arthritis Rheum. 60(8) Pages: 2362-71
  • Peer Reviewed
• [Journal Article] Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis. (2009)
  • Author(s): Kanayama M, Kurotaki D, Morimoto J, Asano T, Matsui Y, Nakayama Y, Saito Y, Ito K, Kimura C, Iwasaki N, Suzuki K, Harada T, Li HM, Uehara J, Miyazaki T, Minami A, Kon S, Uede T.
  • Journal Title: J. Immunol 182(12) Pages: 8015-25
  • Peer Reviewed
• [Journal Article] The differential amino acid requirement within osteopontin in alpha 4 and alpha9 integrin-mediated cell binding and migration. (2009)
  • Author(s): Ito K, Kon S, Nakayama Y, Kurotaki D, Saito Y, Kanayama M, Kimura C, Diao H, Morimoto J, Matsui Y, Uede T.
  • Journal Title: Matrix Biol. 28(1) Pages: 11-9
  • Peer Reviewed
• [Journal Article] The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration (2009)
  • Author(s): K.Ito
  • Journal Title: Matrix Biol. 28 Pages: 11-19
  • Peer Reviewed
• [Journal Article] Aplpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis (2009)
  • Author(s): M.Kanayama
  • Journal Title: J Immunol. 182 Pages: 8015-8025
  • Peer Reviewed
• [Journal Article] Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice (2009)
  • Author(s): Y.Matsui
  • Journal Title: Arthritis Rheum. 60 Pages: 2362-2371
  • Peer Reviewed
• [Journal Article] Down-regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits (2009)
  • Author(s): D.Takahashi
  • Journal Title: Arthritis Rheum. 60 Pages: 2372-2380
  • Peer Reviewed
• [Journal Article] Regulatory role of DC-derived osteopontin in systemic Allergen sensitization (2009)
  • Author(s): M.Kurokawa
  • Journal Title: Eur J Immunol. 39 Pages: 3323-3330
  • Peer Reviewed
• [Journal Article] The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration (2009)
  • Author(s): K. Ito S. Kon, Y. Nakayama, D. Kurotaki, Y. Saito, M. Kanayama, C. Kimura, H. Diao, J. Morimoto, Y. Matsui, T. Uede
  • Journal Title: Matrix Biol 28 Pages: 11-19
  • Peer Reviewed
• [Journal Article] Osteopontin regulates development and function of invariant natural killer T cells. (2008)
  • Author(s): Diao H, Iwabuchi K, Ki L, Onoe K, Van KL, Kon S, Saito Y, Morimoto J, Denhardt DT, Rittling S, Uede T
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A. 105(41) Pages: 15884-9
  • Peer Reviewed
• [Journal Article] Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor. (2008)
  • Author(s): Teague RM, Greengerg PD, Fowler C, Huang MZ, Tan X, Morimoto J, Dosett ML, Huseby ES, Ohlen C
  • Journal Title: Immunity 28(5) Pages: 662-74
  • Peer Reviewed
• [Journal Article] Osteopontin is dispensable for protection against high load systemic fungal infection (2008)
  • Author(s): I. Sato, N. Yamamoto, SR. Rittling, DT. Denhardt, M. Hino, J. Morimoto, F. Sakai, A. Fujie, T. Uede
  • Journal Title: Int Immunopharmacol 8 Pages: 1441-1448
  • Peer Reviewed
• [Journal Article] Osteopontin regulates development and function of invariant natural killer T cells (2008)
  • Author(s): H. Diao, K. Iwabuchi, L. Li, K. Onoe, L. Van, Kaer, S. Kon, Y. Saito, J. Morimoto, DT. Denhardt, SR. Rittling, T. Uede
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 15884-15889
  • Peer Reviewed
• [Journal Article] Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor (2008)
  • Author(s): Teague RM, Greenberg PD, Fowler C, Huang MZ, Tan X, Morimoto J, Dossett ML, Huseby ES, Ohlen C.
  • Journal Title: Immunity 28 Pages: 662-674
  • Peer Reviewed
• [Presentation] Osteopontin deficiency promotes secondary immune response to influenza A virus infection, possibly by regulating the maintenance of virus-specific memory CD8+ T cells. (2009)
  • Author(s): Morimoto J, Sato K, Kida H, Miyazaki T, Uede T
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪
• [Presentation] インフルエンザAウイルス感染防御免疫応答におけるOpnの機能解析 (2009)
  • Author(s): 森本純子, 佐藤佳代子, 伊藤甲雄, 中山洋佑, 松井裕, 喜田宏, 宮崎忠昭, 上出利光
  • Organizer: 第9回オステオポンチン研究会
  • Place of Presentation: 札幌
• [Presentation] Regulation of T Cell Responses by a Distinct Subset of Resident Splenic Macrophages (2009)
  • Author(s): 黒滝大翼
  • Organizer: 1st International Conference on Immune Tolerance
  • Place of Presentation: ボストン Seaport Hotel(イギリス)
• [Presentation] 組織固着マクロファージサブセットによるT細胞免疫応答制御機構の解明 (2009)
  • Author(s): 黒滝大翼
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
• [Presentation] α9インテグリンは関節炎の発症に重要な微小環境を構成する (2009)
  • Author(s): 金山剛士
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Regulation of T cell responses by a distinct subset of resident splenic macrophages (2009)
  • Author(s): 黒滝大翼
  • Organizer: マクロファージ分子細胞生物学国際シンポジウム
  • Place of Presentation: 金沢KKRホテル
• [Presentation] 実験的自己免疫性脳脊髄炎におけるα9インテグリンの機能解析 (2009)
  • Author(s): 伊藤甲雄
  • Organizer: 第20回生体防御学会学術集会
  • Place of Presentation: 東京医科歯科大学
• [Presentation] 心筋梗塞におけるSyndecan-4の機能解析 (2009)
  • Author(s): 松井裕
  • Organizer: 第9回オステオポンチン研究会
  • Place of Presentation: 北海道大学
• [Presentation] インフルエンザAウイルス感染防御免疫応答におけるOpnの機能解析 (2009)
  • Author(s): 森本純子
  • Organizer: 第9回オステオポンチン研究会
  • Place of Presentation: 北海道大学
• [Presentation] Regulation of T cell responses by a novel subset of resident splenic macrophages (2009)
  • Author(s): 黒滝大翼
  • Organizer: 第9回オステオポンチン研究会
  • Place of Presentation: 北海道大学
• [Presentation] Synovial fibroblasts and macrophages differentially contributes to the development of autoimmune arthritis viaα9 integrin (2009)
  • Author(s): 金山剛士
  • Organizer: 第9回オステオポンチン研究会
  • Place of Presentation: 北海道大学
• [Presentation] Administration of Osteopontin small interfering RNA ameliorates experi mental autoimmune uveoretinitis model in mice (2009)
  • Author(s): Kazuya Iwabuchi
  • Organizer: 第9回オステオポンチン研究会
  • Place of Presentation: 北海道大学
• [Presentation] 関節リウマチにおけるα9インテグリン―リガンド間相互作用の解析 (2009)
  • Author(s): 浅野毅
  • Organizer: 第24回日本整形外科学会基礎学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Regulation of T Cell Responses by a Distinct Subset of Resident Splenic Macrophages (2009)
  • Author(s): 黒滝大翼
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] The interaction of α9 integrin and its ligands contributes to the development of Rheumatoid Arthritis (2009)
  • Author(s): 浅野毅
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Osteopontin deficiency promotes secondary immune response to influenza A virus infection, possibly by regulating the maintenance of virus-specific memory CD8^+ T cells (2009)
  • Author(s): 森本純子
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Synovial fibroblasts and macrophages differentially contributes to the development of autoimmune arthritis viaα9 integrin (2009)
  • Author(s): 金山剛士
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Alpha9 integrin is involved in the development of experimental autoimmune encephalomyelitis by regulating inflammatory cell migration from draining lymph node to central nervous systems (2009)
  • Author(s): 伊藤甲雄
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 脾臓に存在するマクロファージサブセットの役割 (2008)
  • Author(s): 黒滝大翼、森本純子、上出利光
  • Organizer: 第41回北海道病理談話会
  • Place of Presentation: 札幌(北海道大学)
  • Year and Date: 2008-09-20
• [Presentation] 自己免疫性関節炎の発症におけるα9インテグリンの機能解析 (2008)
  • Author(s): 金山剛士、黒滝大翼、森本純子, 上出利光
  • Organizer: 第41回北海道病理談話会
  • Place of Presentation: 札幌(北海道大学)
  • Year and Date: 2008-09-20
• [Presentation] α9インテグリンは創傷治癒過程において皮膚線維芽細胞の遊走を調節する (2008)
  • Author(s): 中山洋佑、黒滝大翼、森本純子, 上出利光
  • Organizer: 第41回北海道病理談話会
  • Place of Presentation: 札幌(北海道大学)
  • Year and Date: 2008-09-20
• [Presentation] 感染防御免疫応答におけるオステオポンチンの機能 (2008)
  • Author(s): 森本純子, 松井裕, 上出利光
  • Organizer: 3学会合同大会(第37回日本インターフェロン・サイトカイン学会学術集会、第19回日本生体防御学会学術総会、第45回補体シンポジウム)
  • Place of Presentation: 札幌
• [Presentation] The interaction of alpha9 integrin with its ligands regulates the development of rheumatoid arthritis. (2008)
  • Author(s): Morimoto J, Kanayama M, Kurotaki D, Asano T, Nakayama Y, Ito K, Saito Y, Kimura C, Harada T, Mei LH, Uehara J, Miyazaki T, Uede T, Kon S.
  • Organizer: 2nd International Conference on Osteoimmunology
  • Place of Presentation: Rhodes, Greece
• [Presentation] The interaction of alpha9 integrin with its ligands regulates the development of rheumatoid arthritis (2008)
  • Author(s): Morimoto Junko, Kanayama Masashi, Kurotaki Daisuke, Asano Tsuyoshi, Nakayama Yosuke, Ito Koyu, Saito Yoshinari, Kimura Chiemi, Harada Tatsuhiro, LH. Mei, Uehara Jun, Miyazaki Tadaaki, Uede Toshimitsu, Kon Shigeyuki
  • Organizer: 2nd International Conference on OsAeoimmunology : Interactions of the Immune and Skeletal Systems
  • Place of Presentation: ギリシャロードス島(ヒルトンカンファレンスセンター)
• [Presentation] オステオポンチン阻害による実験的自己免疫性網膜ぶどう膜炎の炎症制御 (2008)
  • Author(s): 岩渕和也、北村瑞、岩田大樹、今重之、木村千恵美、齋藤善也, 森本純子、大野重昭、上出利光, 小野江和則
  • Organizer: 第8回オステオポンチン研究会
  • Place of Presentation: 札幌(北海道大学)
• [Presentation] 関節炎の発症におけるα9インテグリンの役割 (2008)
  • Author(s): 金山剛士、黒滝大翼、森本純子, 上出利光
  • Organizer: 第8回オステオポンチン研究会
  • Place of Presentation: 札幌(北海道大学)
• [Presentation] α9インテグリン陽性脾臓マクロファージの機能 (2008)
  • Author(s): 黒滝大翼、森本純子、上出利光
  • Organizer: 第8回オステオポンチン研究会
  • Place of Presentation: 札幌(北海道大学)
• [Presentation] α9インテグリンは創傷治癒過程において皮膚線維芽細胞の遊走を調節する (2008)
  • Author(s): 中山洋佑、黒滝大翼、今重之、森本純子、松井裕、上出利光
  • Organizer: 第8回オステオポンチン研究会
  • Place of Presentation: 札幌(北海道大学)
• [Presentation] オステオポンチンはインフルエンザウイルス感染時の病態形成に関与する (2008)
  • Author(s): 佐藤佳代子、森本純子、高田礼人、喜田宏、上出利光、宮崎忠昭
  • Organizer: 第8回オステオポンチン研究会
  • Place of Presentation: 札幌(北海道大学)
• [Presentation] Osteopontin is dispensable for protection against high load systemic fungal infection (2008)
  • Author(s): Ikuko Sato, Nobuchika Yamamoto, Susan R. Rittling, David T. Denhardt, Motohiro Hino, Junko Morimoto, Fumihiko Sakai, Akihiko Fujie, Toshimitsu Uede
  • Organizer: 第8回オステオポンチン研究会
  • Place of Presentation: 札幌(北海道大学)
• [Presentation] α9β1 integrin regulates the migration of dermal fibroblasts during the process of wound healing (2008)
  • Author(s): Nakayama Yosuke, Kurotaki Daisuke, Morimoto Junko, Uede Toshimitsu
  • Organizer: 第38回日本免疫学会総会学術集会
  • Place of Presentation: 京都(国立京都国際会館)
• [Presentation] The interaction of α9 integrin and its ligands provides microenvironments critical for the development of autoimmune arthritis (2008)
  • Author(s): Kanayama Masashi, Kurotaki Daisuke, Nakayama Yosuke, Morimoto Junko, Uede Toshimitsu
  • Organizer: 第38回日本免疫学会総会学術集会
  • Place of Presentation: 京都(国立京都国際会館)
• [Presentation] The unique role of α9 integrin positive splenic macrophages (2008)
  • Author(s): Kurotaki Daisuke, Morimoto Junko, Nakayama Yosuke, Narita Yoshinori, Nishimura Takashi, Uede Toshimitsu
  • Organizer: 第38回日本免疫学会総会学術集会
  • Place of Presentation: 京都(国立京都国際会館)
• [Presentation] Significance of osteopontin in mortality by influenza A virus Infection (2008)
  • Author(s): Sato Kayoko, Morimoto Junko, Takada Ayato, Kida Hiroshi, Uede Toshimitsu, Miyazaki Tadaaki
  • Organizer: 第38回日本免疫学会総会学術集会
  • Place of Presentation: 京都(国立京都国際会館)
• [Book] 炎症・再生医学事典(オステオポンチン) (2009)
  • Author(s): 森本純子、上出利光
  • Publisher: 朝倉書店
• [Book] 炎症・再生医学事典 (2009)
  • Author(s): 森本純子
  • Total Pages: 3
  • Publisher: 朝倉書店
• [Book] Medical Science Digest(オステオポンチンと自己免疫疾患) (2008)
  • Author(s): 森本純子、上出利光