| Project/Area Number |
20790366
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KITAMURA Hidemitsu Hokkaido University, 遺伝子病制御研究所, 准教授 (40360531)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 免疫監視・腫瘍免疫 / 樹状細胞 / クロスプレゼンテーション / MHC / CTL / サイトカイン |
|---|
| Research Abstract |
Uptake of tumor-antigen by dendritic cells (DCs) and generation of tumor-antigen specific killer T cells by the cross-presentation were evaluated in vitro and in vivo. Although IL-6, a major cytokine produced under tumor-bearing state, enhanced the engulfment of tumor cells, it reduced antigen-presenting ability by DCs. On the other hand, the antigen presentation by DCs were increased in the presence of TLR ligands and IFN-γ. In the near future, development of effective generation of tumor-antigen specific T cells by DCs would be a promising strategy for cancer immunotherapy.
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