Senescence and maintenance mechanism of antigen-specific CD8+ T cells upon repeatitive antigenic challenges.

• Project/Area Number: 20790369
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: The University of Tokyo
• Principal Investigator: KURACHI Makoto The University of Tokyo, 大学院・医学系研究科, 助教 (00396722)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 免疫記憶 / 老化 / CD8陽性T細胞 / 二次リンパ組織

Research Abstract

Although it is suggested that the nature of memory CTL changes over repeated antigenic challenges, molecular characteristics of distinct memory CTL with different number of antigen experience are largely unknown. In this study, we analyzed genome wide transcriptome of primary and secondary memory CTL using a next-generation DNA sequencer. Memory CTL changes molecular signature as they experience the responses and memory CTL senescence differs from exhaustion.

Research Products

• [Journal Article] Bone marrow graft-versus-host disease: early destruction of hematopoietic niche following MHC-mismatched hematopoietic stem cell transplantation. (2010)
  • Author(s): Shono Y, Kurachi M, et al
  • Journal Title: Blood (In press)
  • Peer Reviewed
• [Journal Article] Bone marrow graft-versus-host disease : early destruction of hematopoietic niche following MHC-mismatched hematopoietic stem cell transplantation (2010)
  • Author(s): Shono Y
  • Journal Title: Blood (掲載確定(印刷中))
  • Peer Reviewed
• [Presentation] メモリーCTLの老化に伴う遺伝子発現解析 (2009)
  • Author(s): 倉知慎, 他
  • Organizer: 第39回日本免疫学会総会・学術総会
  • Place of Presentation: 大阪(グランキューブ大阪)
  • Year and Date: 2009-12-03
• [Presentation] Primary memory CTL preferentially accumulate in secondary lymphoid organs (2008)
  • Author(s): 倉知慎, 他
  • Organizer: 第38回日本免疫学会総会・学術総会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2008-12-02
• [Remarks]
  • URL: http://www.prevent.m.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.prevent.m.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.prevent.m.u-tokyo.ac.jp/