The role of DCIR in the immune regulation

• Project/Area Number: 20790370
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: The University of Tokyo
• Principal Investigator: FUJIKADO Noriyuki The University of Tokyo, 医科学研究所, 助教 (90447334)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 自己免疫 / 免疫寛容

Research Abstract

In this study, it was revealed that DCIR functions not only the development of arthritis, but also the development of other immune-related diseases such as other experimental autoimmune and allergic diseases. Moreover, we identified an endogenous carbohydrate ligand for DCIR, and showed that the ligand can input inhibitory signal to DCIR. And the role of DCIR in the bone metabolism, which was discovered during the pathological analysis of arthritis, is also examined and found that DCIR functions not only in DCs, but also in osteoclasts and osteoblasts. These findings should support the development of new therapeutics for immune-related diseases.

Research Products

• [Journal Article] Dectin-2 Recognition of alpha-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans. (2010)
  • Author(s): Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, Fujikado N, Kusaka T, Kubo S, Chung SH, Komatsu R, Miura N, Adachi Y, Ohno N, Shibuya K, Yamamoto N, Kawakami K, Yamasaki S, Saito T, Akira S, Iwakura Y.
  • Journal Title: Immunity. Pages: 681-91
• [Journal Article] Dectin-2 is crucial for the defense against Candida albicans in mice by recognizing α-mannans and inducing Th17 differentiation (2010)
  • Author(s): Saijo S., et al.
  • Journal Title: Immunity (印刷中)
  • Peer Reviewed
• [Journal Article] Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. (2009)
  • Author(s): Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y.
  • Journal Title: Immunity. Pages: 108-19
• [Journal Article] Differential roles of interleukin-17 A and-17 F in host defense against mucoepithelial bacterial infection and allergic responses (2009)
  • Author(s): Ishigame H., et.al.
  • Journal Title: Immunity 30(1) Pages: 108-19
  • Peer Reviewed
• [Journal Article] Iwakura Y. Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. (2008)
  • Author(s): Fujikado N, Saijo S, Yonezawa T, Shimamori K, Ishii A, Sugai S, Kotaki H, Sudo K, Nose M
  • Journal Title: Nature Medicine. Pages: 176-80
• [Presentation] The role of Dcir in the autoimmune and bone metabolic diseases. (2009)
  • Author(s): Fujikado N., et al
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] The role of Dcir in the autoimmune and bone metabolic diseases (2009)
  • Author(s): 藤門範行, et al.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] c型レクチンを標的とした免疫・骨代謝疾患の発症機構の解明と治療薬の開発 (2009)
  • Author(s): 藤門範行
  • Organizer: 第17回幹細胞治療フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2009-07-30
• [Presentation] C型レクチンを標的とした免疫・骨代謝疾患の発症機構の解明と治療薬の開発 (2009)
  • Author(s): 藤門範行
  • Organizer: 第17回幹細胞治療フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2009-07-30
• [Presentation] The role of Dcir in the inflammatory diseases. (2009)
  • Author(s): Fujikado N., et al
  • Organizer: World Congress on Inflammation 2009
  • Place of Presentation: 東京
  • Year and Date: 2009-07-06
• [Presentation] The role of Dcir in the inflammatory diseases (2009)
  • Author(s): 藤門範行, et al.
  • Organizer: World Congress on Inflammation 2009
  • Place of Presentation: 東京
  • Year and Date: 2009-07-06
• [Presentation] 自己免疫疾患及び骨代謝疾患におけるDCIRの役割の解析 (2009)
  • Author(s): 藤門範行, ら
  • Organizer: 第74回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-06-26
• [Presentation] 新たな自己免疫疾患モデル;Dcir欠損マウスの解析 (2009)
  • Author(s): 藤門範行, ら
  • Organizer: 第56回日本実験動物学会総会
  • Place of Presentation: 大宮
  • Year and Date: 2009-05-14
• [Presentation] The role of Dcir in the development of autoimmune diseases. (2008)
  • Author(s): Fujikado N., et al
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] The role of Dcir in the development of autoimmune diseases (2008)
  • Author(s): Fujikado N., et.al.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] The role of DCIR in the development of autoimmune diseases. (2008)
  • Author(s): Fujikado N., et al
  • Organizer: 7th Joint Conference of the International Cytokine Society and International Society for Interferon and Cytokine Research
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2008-10-13
• [Presentation] The role of DCIR in the development of autoimmune diseases (2008)
  • Author(s): Fujikado N., et.al.
  • Organizer: 7th Joint Conference of the International Cytokine Society and International Society for Interferon and Cvtokine Research
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2008-10-13
• [Presentation] Dcirの欠損は樹状細胞の過剰増殖に起因する自己免疫疾患発症の原因となる (2008)
  • Author(s): 藤門範行, ら
  • Organizer: 第73回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-11
• [Presentation] Dcirの欠損は樹状細胞の過剰増殖に起因する自己免疫疾患発症の原因となる (2008)
  • Author(s): 藤門範行
  • Organizer: 第73回日本インターフェロン・サイトカイン学会学術集会(Joint Conference in Sapporo 2008)
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-11
• [Presentation] The role of Dcir in the development of autoimmune diseases. (2008)
  • Author(s): 藤門範行, ら
  • Organizer: 第三回免疫疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-11
• [Presentation] The role of Dcir in the development of autoimmune diseases (2008)
  • Author(s): 藤門範行
  • Organizer: 第三回免疫疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-11
• [Presentation] 関節リウマチモデルマウスのトランスクリプトーム解析より得られた新たな自己免疫疾患モデルDcir欠損マウスの解析 (2008)
  • Author(s): 藤門範行, ら
  • Organizer: 第55回日本実験動物学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-17
• [Presentation] 関節リウマチモデルマウスのトランスクリプトーム解析より得られた新たな自己免疫疾患モデルDcir欠損マウスの解析 (2008)
  • Author(s): 藤門範行
  • Organizer: 第55回日本実験動物学会総会(日本実験動物科学技術2008)
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-17
• [Book] 関節リウマチ-寛解を目指す治療の新時代- (2010)
  • Author(s): 藤門範行, ら
  • Publisher: 日本臨床社
• [Book] 病態関連分子の探索と創薬への応用. 関節リウマチ―寛解を目指す治療の新時代―[第2版] (2010)
  • Author(s): 藤門範行, ら
  • Total Pages: 8
  • Publisher: 日本臨床社
• [Book] Dcirと自己免疫疾患 (2009)
  • Author(s): 藤門範行, ら
  • Publisher: 最新医学社
• [Book] 樹状細胞の抑制型受容体 (2009)
  • Author(s): 藤門範行, ら
  • Publisher: ニュー・サイエンス社
• [Book] Medical Science Digest「樹状細胞の抑制型受容体」 (2009)
  • Author(s): 藤門範行, ら
  • Total Pages: 2
  • Publisher: ニュー・サイエンス社
• [Book] 最新医学「Dcir と自己免疫疾患」 (2009)
  • Author(s): 藤門範行, ら
  • Total Pages: 6
  • Publisher: 最新医学社
• [Book] Medical Science Digest「樹状細胞の抑制型受容体」 (2009)
  • Author(s): 藤門範行
  • Total Pages: 2
  • Publisher: ニュー・サイエンス社
• [Book] C型レクチンによるコラーゲン誘導関節炎の制御 (2008)
  • Author(s): 藤門範行, ら
  • Publisher: 科学評論社
• [Book] 自己免疫疾患におけるDcirの役割 (2008)
  • Author(s): 藤門範行, ら
  • Publisher: 羊土社
• [Book] 臨床免疫・アレルギー科「C型レクチンによるコラーゲン誘導関節炎の制御」 (2008)
  • Author(s): 藤門範行
  • Total Pages: 7
  • Publisher: 科学評論社
• [Book] 実験医学(2008増刊)樹状細胞による免疫制御と臨床応用「自己免疫疾患におけるDcirの役割」 (2008)
  • Author(s): 藤門範行
  • Total Pages: 6
  • Publisher: 羊土社
• [Patent(Industrial Property Rights)] 樹状細胞免疫受容体刺激剤 (2010)
  • Inventor(s): 岩倉洋一郎、藤門範行、馬光宇
  • Industrial Property Rights Holder: 岩倉洋一郎、藤門範行、馬光宇
  • Industrial Property Number: 2010-037204
  • Filing Date: 2010-02-23
• [Patent(Industrial Property Rights)] 樹状細胞免疫受容体刺激剤 (2010)
  • Inventor(s): 岩倉洋一郎, ら
  • Industrial Property Rights Holder: 岩倉洋一郎, ら
  • Industrial Property Number: 2010-037204
  • Filing Date: 2010-02-23