The role of DCIR in the immune regulation
| Project/Area Number |
20790370
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUJIKADO Noriyuki The University of Tokyo, 医科学研究所, 助教 (90447334)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自己免疫 / 免疫寛容 |
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| Research Abstract |
In this study, it was revealed that DCIR functions not only the development of arthritis, but also the development of other immune-related diseases such as other experimental autoimmune and allergic diseases. Moreover, we identified an endogenous carbohydrate ligand for DCIR, and showed that the ligand can input inhibitory signal to DCIR. And the role of DCIR in the bone metabolism, which was discovered during the pathological analysis of arthritis, is also examined and found that DCIR functions not only in DCs, but also in osteoclasts and osteoblasts. These findings should support the development of new therapeutics for immune-related diseases.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Dectin-2 Recognition of alpha-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans.2010
Author(s)
Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, Fujikado N, Kusaka T, Kubo S, Chung SH, Komatsu R, Miura N, Adachi Y, Ohno N, Shibuya K, Yamamoto N, Kawakami K, Yamasaki S, Saito T, Akira S, Iwakura Y.
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Related Report
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[Journal Article] Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.2009
Author(s)
Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y.
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