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The role of DCIR in the immune regulation

Research Project

Project/Area Number 20790370
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionThe University of Tokyo

Principal Investigator

FUJIKADO Noriyuki  The University of Tokyo, 医科学研究所, 助教 (90447334)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords自己免疫 / 免疫寛容
Research Abstract

In this study, it was revealed that DCIR functions not only the development of arthritis, but also the development of other immune-related diseases such as other experimental autoimmune and allergic diseases. Moreover, we identified an endogenous carbohydrate ligand for DCIR, and showed that the ligand can input inhibitory signal to DCIR. And the role of DCIR in the bone metabolism, which was discovered during the pathological analysis of arthritis, is also examined and found that DCIR functions not only in DCs, but also in osteoclasts and osteoblasts. These findings should support the development of new therapeutics for immune-related diseases.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (18 results) Book (11 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Dectin-2 Recognition of alpha-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans.2010

    • Author(s)
      Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, Fujikado N, Kusaka T, Kubo S, Chung SH, Komatsu R, Miura N, Adachi Y, Ohno N, Shibuya K, Yamamoto N, Kawakami K, Yamasaki S, Saito T, Akira S, Iwakura Y.
    • Journal Title

      Immunity.

      Pages: 681-91

    • Related Report
      2009 Final Research Report
  • [Journal Article] Dectin-2 is crucial for the defense against Candida albicans in mice by recognizing α-mannans and inducing Th17 differentiation2010

    • Author(s)
      Saijo S., et al.
    • Journal Title

      Immunity (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.2009

    • Author(s)
      Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y.
    • Journal Title

      Immunity.

      Pages: 108-19

    • Related Report
      2009 Final Research Report
  • [Journal Article] Differential roles of interleukin-17 A and-17 F in host defense against mucoepithelial bacterial infection and allergic responses2009

    • Author(s)
      Ishigame H., et.al.
    • Journal Title

      Immunity 30(1)

      Pages: 108-19

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iwakura Y. Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells.2008

    • Author(s)
      Fujikado N, Saijo S, Yonezawa T, Shimamori K, Ishii A, Sugai S, Kotaki H, Sudo K, Nose M
    • Journal Title

      Nature Medicine.

      Pages: 176-80

    • Related Report
      2009 Final Research Report
  • [Presentation] The role of Dcir in the autoimmune and bone metabolic diseases.2009

    • Author(s)
      Fujikado N., et al
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of Dcir in the autoimmune and bone metabolic diseases2009

    • Author(s)
      藤門範行, et al.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] c型レクチンを標的とした免疫・骨代謝疾患の発症機構の解明と治療薬の開発2009

    • Author(s)
      藤門範行
    • Organizer
      第17回幹細胞治療フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2009-07-30
    • Related Report
      2009 Final Research Report
  • [Presentation] C型レクチンを標的とした免疫・骨代謝疾患の発症機構の解明と治療薬の開発2009

    • Author(s)
      藤門範行
    • Organizer
      第17回幹細胞治療フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of Dcir in the inflammatory diseases.2009

    • Author(s)
      Fujikado N., et al
    • Organizer
      World Congress on Inflammation 2009
    • Place of Presentation
      東京
    • Year and Date
      2009-07-06
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of Dcir in the inflammatory diseases2009

    • Author(s)
      藤門範行, et al.
    • Organizer
      World Congress on Inflammation 2009
    • Place of Presentation
      東京
    • Year and Date
      2009-07-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自己免疫疾患及び骨代謝疾患におけるDCIRの役割の解析2009

    • Author(s)
      藤門範行, ら
    • Organizer
      第74回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 新たな自己免疫疾患モデル;Dcir欠損マウスの解析2009

    • Author(s)
      藤門範行, ら
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      大宮
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] The role of Dcir in the development of autoimmune diseases.2008

    • Author(s)
      Fujikado N., et al
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-02
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of Dcir in the development of autoimmune diseases2008

    • Author(s)
      Fujikado N., et.al.
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of DCIR in the development of autoimmune diseases.2008

    • Author(s)
      Fujikado N., et al
    • Organizer
      7th Joint Conference of the International Cytokine Society and International Society for Interferon and Cytokine Research
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2008-10-13
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of DCIR in the development of autoimmune diseases2008

    • Author(s)
      Fujikado N., et.al.
    • Organizer
      7th Joint Conference of the International Cytokine Society and International Society for Interferon and Cvtokine Research
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2008-10-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dcirの欠損は樹状細胞の過剰増殖に起因する自己免疫疾患発症の原因となる2008

    • Author(s)
      藤門範行, ら
    • Organizer
      第73回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Dcirの欠損は樹状細胞の過剰増殖に起因する自己免疫疾患発症の原因となる2008

    • Author(s)
      藤門範行
    • Organizer
      第73回日本インターフェロン・サイトカイン学会学術集会(Joint Conference in Sapporo 2008)
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of Dcir in the development of autoimmune diseases.2008

    • Author(s)
      藤門範行, ら
    • Organizer
      第三回免疫疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-11
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of Dcir in the development of autoimmune diseases2008

    • Author(s)
      藤門範行
    • Organizer
      第三回免疫疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチモデルマウスのトランスクリプトーム解析より得られた新たな自己免疫疾患モデルDcir欠損マウスの解析2008

    • Author(s)
      藤門範行, ら
    • Organizer
      第55回日本実験動物学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチモデルマウスのトランスクリプトーム解析より得られた新たな自己免疫疾患モデルDcir欠損マウスの解析2008

    • Author(s)
      藤門範行
    • Organizer
      第55回日本実験動物学会総会(日本実験動物科学技術2008)
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Book] 関節リウマチ-寛解を目指す治療の新時代-2010

    • Author(s)
      藤門範行, ら
    • Publisher
      日本臨床社
    • Related Report
      2009 Final Research Report
  • [Book] 病態関連分子の探索と創薬への応用. 関節リウマチ―寛解を目指す治療の新時代―[第2版]2010

    • Author(s)
      藤門範行, ら
    • Total Pages
      8
    • Publisher
      日本臨床社
    • Related Report
      2009 Annual Research Report
  • [Book] Dcirと自己免疫疾患2009

    • Author(s)
      藤門範行, ら
    • Publisher
      最新医学社
    • Related Report
      2009 Final Research Report
  • [Book] 樹状細胞の抑制型受容体2009

    • Author(s)
      藤門範行, ら
    • Publisher
      ニュー・サイエンス社
    • Related Report
      2009 Final Research Report
  • [Book] Medical Science Digest「樹状細胞の抑制型受容体」2009

    • Author(s)
      藤門範行, ら
    • Total Pages
      2
    • Publisher
      ニュー・サイエンス社
    • Related Report
      2009 Annual Research Report
  • [Book] 最新医学「Dcir と自己免疫疾患」2009

    • Author(s)
      藤門範行, ら
    • Total Pages
      6
    • Publisher
      最新医学社
    • Related Report
      2009 Annual Research Report
  • [Book] Medical Science Digest「樹状細胞の抑制型受容体」2009

    • Author(s)
      藤門範行
    • Total Pages
      2
    • Publisher
      ニュー・サイエンス社
    • Related Report
      2008 Annual Research Report
  • [Book] C型レクチンによるコラーゲン誘導関節炎の制御2008

    • Author(s)
      藤門範行, ら
    • Publisher
      科学評論社
    • Related Report
      2009 Final Research Report
  • [Book] 自己免疫疾患におけるDcirの役割2008

    • Author(s)
      藤門範行, ら
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report
  • [Book] 臨床免疫・アレルギー科「C型レクチンによるコラーゲン誘導関節炎の制御」2008

    • Author(s)
      藤門範行
    • Total Pages
      7
    • Publisher
      科学評論社
    • Related Report
      2008 Annual Research Report
  • [Book] 実験医学(2008増刊)樹状細胞による免疫制御と臨床応用「自己免疫疾患におけるDcirの役割」2008

    • Author(s)
      藤門範行
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 樹状細胞免疫受容体刺激剤2010

    • Inventor(s)
      岩倉洋一郎、藤門範行、馬光宇
    • Industrial Property Rights Holder
      岩倉洋一郎、藤門範行、馬光宇
    • Industrial Property Number
      2010-037204
    • Filing Date
      2010-02-23
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 樹状細胞免疫受容体刺激剤2010

    • Inventor(s)
      岩倉洋一郎, ら
    • Industrial Property Rights Holder
      岩倉洋一郎, ら
    • Industrial Property Number
      2010-037204
    • Filing Date
      2010-02-23
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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