Regulation of leukocyte trafficking and immune responses by nepmucin
| Project/Area Number |
20790374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
UMEMOTO Eiji Osaka University, 医学系研究科, 助教 (90452440)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 接着分子 / 免疫学 / 白血球動態 / 免疫応答 / 高内皮細静脈 |
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| Research Abstract |
Nepmucin is an Ig-domain-containing adhesion molecule expressed in certain types of vascular endothelial cells. We found that nepmucin is localized to interendothelial contacts and mediates homotypic cell adhesion. Nepmucin showed enhanced lymphocyte transendothelial migration by its Ig domain. We also found that nepmucin mediates uptake of apoptotic cells by the interaction of phosphatidylserine, which appears on the outer leaflet of the plasma membrane in apoptotic cells. These results indicate that nepmucin plays multiple physiological roles.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions2008
Author(s)
Nakasaki T. Tanaka, T. Okudaira, S., Hirosawa, M., Umemoto, E., Otani, K., Jin, S., Bai, Z., Hayasaka, H., Fukui, Y., Aozasa, K., Fujita, N., Tsuruo, T., Ozono, K., Aoki, J., Miyasaka, M.
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Journal Title
Am. J. Pathol 173
Pages: 1566-1576
Related Report
Peer Reviewed
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