• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research of the Airway Apoptosis after Lung Transplant Rejection

Research Project

Project/Area Number 20790375
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionOkayama University

Principal Investigator

OKAZAKI Mikio  Okayama University, レジデント (50467750)

Research Collaborator YAMANE Masaomi  岡山大学, 腫瘍・胸部外科, 助教 (20432643)
DANIEL Kreisel  ワシントン大学, 助教
YOSHIDA Osamu  岡山大学, 腫瘍・胸部外科, 研究生
YAMAMOTO Sumiharu  岡山大学, 腫瘍・胸部外科, 研究生
KAWAKAMI Tetsuo  岡山大学, 腫瘍・胸部外科, 技官
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords肺移植 / 急性拒絶反応 / 慢性拒絶反応 / 閉塞性細気管支炎 / アポトーシス
Research Abstract

肺移植後の慢性拒絶反応である閉塞性細気管支炎(BO)は肺移植後の長期生存率が他の臓器移植より低い要因であるが、BOに関してはいまだに不明な部分が多い。今までは異所性気管移植モデルがBOの研究に多く用いられてきたが、気管内腔に空気は通過せず、臨床肺移植とかけ離れており、BOのモデルとしては不完全であった。今回、申請者が開発した同所性マウス肺移植モデルを用いて、拒絶反応における気道上皮とアポトーシスの関係について研究した。

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Costimulatory blockade-mediated lung allograft acceptance is abrogated by overexpression of Bcl-2 in the recipient.2009

    • Author(s)
      M. Okazaki, S. Sugimoto, J. Lai, C.G. Kornfeld, R.S. Hotchkiss, S.B. Richardson, W. Li, F.H. Kreisel, H.J. Huang, G.A. Patterson, A.S. Krupnick, A.E. Gelman, D. Kreisel.
    • Journal Title

      Transplant Proc. 41(1)(in press)

      Pages: 385-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Costimulatory blockade-mediated lung allograft acceptance is abrogated by Over expression of Bcl-2 in the recipient.2009

    • Author(s)
      Mikio Okazaki
    • Journal Title

      Transplantation Proceedings 41

      Pages: 385-387

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Costimulatory blockade-mediated lung allograft acceptance is abrogated by overexpression of Bcl-2 in the recipient.2008

    • Author(s)
      Mikio Okazaki
    • Organizer
      XXII International Congress of the Transplantation Society
    • Place of Presentation
      オーストラリア・シドニー
    • Year and Date
      2008-08-12
    • Related Report
      2009 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi