Cross-regulatory mechanisms of innate immunity and autophagy
| Project/Area Number |
20790376
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyushu University |
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Principal Investigator |
TAKAESU Giichi Kyushu University, 医学部, 講師 (60403995)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自然免疫 / オートファジー / TAK1-binding proteins |
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| Research Abstract |
Autophagy is an intracellular bulk degradation system conserved among eukaryotes. In mammals, autophagy plays many physiological roles such as starvation response, protein quality control, host defense and so on. However, the molecular mechanisms of autophagy regulation are not well understood. Here, I focused my study on cross-regulatorymechanisms of innate immunity and autophagy. I found that TAB2 and TAB3, previously characterized as adapter proteins involved in innate immunity, negatively egulate basal autophagy in mammalian cells.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.2009
Author(s)
Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A.
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Journal Title
J Immunol. 182(10)
Pages: 5929-5937
Related Report
Peer Reviewed
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