Identification of molecular mechanisms of zinc signal mediated cytokine production in mast cells
| Project/Area Number |
20790381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMASAKI Satoru The Institute of Physical and Chemical Research, サイトカイン制御研究グループ, 研究員 (30392161)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | サイトカイン産生 / 亜鉛ウエーブ / マスト細胞 / シグナル伝達 / アレルギー反応 / 亜鉛透過性チャネル |
|---|
| Research Abstract |
We have reported that FcεRI-mediated signal induced elevation of intracellular zinc level named zinc wave. In this study, we found that antagonist for voltage-gated calcium channel reduced the zinc wave and knockdown of this protein also reduced zinc wave. Furthermore, we revealed that the signal pathway for cytokine mRNA induction was impaired by the reduction of zinc wave.
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Report
(3 results)
Research Products
(4 results)
