Identification of molecular mechanisms of zinc signal mediated cytokine production in mast cells

Research Project

Project/Area Number	20790381
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Immunology
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	YAMASAKI Satoru The Institute of Physical and Chemical Research, サイトカイン制御研究グループ, 研究員 (30392161)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	サイトカイン産生 / 亜鉛ウエーブ / マスト細胞 / シグナル伝達 / アレルギー反応 / 亜鉛透過性チャネル
Research Abstract	We have reported that FcεRI-mediated signal induced elevation of intracellular zinc level named zinc wave. In this study, we found that antagonist for voltage-gated calcium channel reduced the zinc wave and knockdown of this protein also reduced zinc wave. Furthermore, we revealed that the signal pathway for cytokine mRNA induction was impaired by the reduction of zinc wave.

Report

(3 results)