Persistent infection of Hepatitis C Virus

• Project/Area Number: 20790384
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Tokyo Metropolitan Organization for Medical Research
• Principal Investigator: SEKIGUCHI Satoshi Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 研究員 (10462780)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 持続感染 / 免疫寛容 / 自己免疫 / ワクチン / 炎症

Research Abstract

We generated immunocompetent HCV persistent infection model mice. Using the new model mice, we examined whether HCV recombinant vaccinia viruses (HCV-RVV) could be used as therapeutic vaccines. HCV-RVV cured the pathological changes in mice liver. These results suggest that HCV-RVV could be used as therapeutic vaccine.

Research Products

• [Journal Article] Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins. (2009)
  • Author(s): Machida K, Tsukiyama-Kohara K, Sekiguchi S, Seike E, Tone S, Hayashi Y, Tobita Y, Kasama Y, Shimizu M, Takahashi H, Taya C, Yonekawa H, Tanaka N, Kohara M
  • Journal Title: Gastroenterology 137(1) Pages: 285-96
  • Peer Reviewed
• [Journal Article] 小原道法C型肝炎ウイルスの持続感染機構と病原性 (2009)
  • Author(s): 関口敏、飛田良美
  • Journal Title: メディカル・サイエンス・ダイジェスト Vol.35(6) Pages: 14-17
• [Journal Article] Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins. (2009)
  • Author(s): Keigo Machida
  • Journal Title: Gastroenterology 137 Pages: 285-296
  • Peer Reviewed
• [Journal Article] C型肝炎ウイルスの持続感染機構と病原性 (2009)
  • Author(s): 関口敏
  • Journal Title: メディカル・サイエンス・ダイジェスト 35 Pages: 14-17
• [Presentation] Resolution of HCV chronic hepatitis with immunotherapy using Hepatitis C virus recombinant vaccinia virus in persistent infection model mice (2009)
  • Author(s): Satoshi Sekiguchi
  • Organizer: AASLD's 60th Annual Meeting
  • Place of Presentation: アメリカ・ボストン
  • Year and Date: 2009-10-30
• [Presentation] HCV持続感染モデルマウスにおけるHCV遺伝子組換えワクチニアウイルスの治療効果 (2009)
  • Author(s): 関口敏
  • Organizer: 第57回日本ウイルス学会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-25
• [Presentation] Resolution of HCV chronic hepatitis with immunotherapy using Hepatitis C virus recombinant vaccinia virus in persistent infection model mice AASLD's (2009)
  • Author(s): Satoshi Sekiguchi
  • Organizer: 60th Annual Meeting
  • Place of Presentation: アメリカ(ボストン)
• [Presentation] hcv持続感染モデルマウスにおけるhcv遺伝子組換えワクチニアウイルスの治療効果 (2009)
  • Author(s): 関口敏
  • Organizer: 第57回日本ウイルス学会
  • Place of Presentation: 東京
• [Presentation] Persistent infection of Hepatitis C Virus (2009)
  • Author(s): Satoshi Sekiguchi
  • Organizer: 第68回日本癌学会
  • Place of Presentation: 神奈川
• [Presentation] (2008)
  • Author(s): 関口 敏
  • Organizer: 第12回日本ワクチン学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-11-09
• [Presentation] 新規HCV持続感染モデルマウスの作製とその病態解析 (2008)
  • Author(s): 関口 敏
  • Organizer: 第56回日本ウイルス学会
  • Place of Presentation: 岡山
  • Year and Date: 2008-10-28
• [Presentation] Persistent infection of Hepatitis C virus to get over the acquired immunity system (2008)
  • Author(s): Satoshi Sekiguchi
  • Organizer: 第8回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 兵庫
  • Year and Date: 2008-09-09
• [Presentation] hcv遺伝子組換えワクチニアウイルスの治療ワクチン効果 (2008)
  • Author(s): 関口敏
  • Organizer: 第12回日本ワクチン学会
  • Place of Presentation: 熊本
• [Presentation] 新規hcv持続感染モデルマウスの作製とその病態解析 (2008)
  • Author(s): 関口敏
  • Organizer: 第56回日本ウイルス学会
  • Place of Presentation: 岡山
• [Remarks]
  • URL: http://www.rinshoken.or.jp/
• [Remarks]
  • URL: http://www.rinshoken.or.jp/
• [Remarks]
  • URL: http://www.rinshoken.or.jp/