The investigation into the efficacy of angiotensin receptor blocker against metabolic syndrome

• Project/Area Number: 20790401
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: TOBA Hiroe Kyoto Pharmaceutical University, 薬学部, 助教 (90351270)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 臨床薬理学 / メタボリックシンドローム

Research Abstract

We have demonstrated that telmisartan inhibited renal and aortic injury in the diabetic rat model and these beneficial effects were stronger than those of other angiotensin receptor blocker (ARB), which have exhibitied similar antihypertensive effects to those of telmisartan. In addition, we also showed that treatment with telmisartan suppressed inflammation in the H_2O_2-treated cultured vascular endothelial cells by PPARγ.

Research Products

• [Journal Article] Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice. (2010)
  • Author(s): Kobara M, Noda K, Kitamura M, Okamoto A, Shiraishi T, Toba H, Matsubara H, Nakata T.
  • Journal Title: Cardiovascular Research (in press)
  • Peer Reviewed
• [Journal Article] Oral L-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats. (2010)
  • Author(s): Toba H, Nakamori A, Tanaka Y, Yukiya R, Tatsuoka K, Narutaki M, Tokitaka M, Hariu H, Kobara M, Nakata T.
  • Journal Title: Clininal and Experimental Pharmacology and Physiology 37(1) Pages: 62-68
  • Peer Reviewed
• [Journal Article] Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice (2010)
  • Author(s): Kobara M, Noda K, Kitamura M, Okamoto A, Shiraishi T, Toba H, Matsubara H, Nakata T.
  • Journal Title: Cardiovascular Research (in press)
  • Peer Reviewed
• [Journal Article] Oral L-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats (2010)
  • Author(s): Toba H, Nakamori A, Tanaka Y, Yukiya R, Tatsuoka K, Narutaki M, Tokitaka M, Hariu H, Kobara M, Nakata T.
  • Journal Title: Clininal and Experimental Pharmacology and Physiology 37(1) Pages: 62-68
  • Peer Reviewed
• [Journal Article] Nakata TChronic treatment with recombinant human erythropoietin exerts renoprotective effects beyond hematopoiesis in streptozotocin-induced diabetic rat. (2009)
  • Author(s): Toba H, Sawai N, Morishita M, Murata S, Yoshida M, Nakashima K, Morita Y, Kobara M
  • Journal Title: European Journal of Pharmacology 612(1-3) Pages: 106-114
  • Peer Reviewed
• [Journal Article] Chronic treatment with recombinant human erythropoietin exerts renoprotective effects beyond hematopoiesis in streptozotocin-induced diabetic rat (2009)
  • Author(s): Toba H, Sawai N, Morishita M, Murata S, Yoshida M, Nakashima K, Morita Y, Kobara M, Nakata T
  • Journal Title: European Journal of Pharmacology 612(1-3) Pages: 106-114
  • Peer Reviewed
• [Journal Article] Nakata T Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. (2008)
  • Author(s): Taira M, Toba H, Murakami M, Iga I, Serizawa R, Murata S, Kobara M
  • Journal Title: European Journal of Pharmacology 589(1-3) Pages: 264-271
  • Peer Reviewed
• [Journal Article] Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis (2008)
  • Author(s): Hayashi H, Kobara M, Abe M, Tanaka N, Gouda E, Toba H, Yamada H, Tatsumi T, Nakata T, Matsubara H.
  • Journal Title: Hypertension Research 31(2) Pages: 363-375
  • NAID: 10024360250
  • Peer Reviewed
• [Journal Article] Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats (2008)
  • Author(s): Taira M, Toba H, Murakami M, Iga I, Serizawa R, Murata S, Kobara M, Nakata T
  • Journal Title: European Journal of Pharmacology 589(1-3) Pages: 264-271
  • Peer Reviewed
• [Journal Article] Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis (2008)
  • Author(s): Hayashi H, Kobara M, Abe M, Tanaka N, Gouda E, Toba H, Yamada H, Tatsumi T, Nakata T, Matsubara H
  • Journal Title: Hypertension Research 31(2) Pages: 363-375
  • NAID: 10024360250
  • Peer Reviewed
• [Presentation] Pitavastatin inhibited diabetic nephropathy and decreased renal renin-angiotensin-aldosterone system in rats. (2009)
  • Author(s): Hiroe Toba, Nobuyoshi Imai, Ryoko Serizawa, Tamotsu Takahashi, Takuya Mitani, Miyuki Kobara, Tetsuo Nakata.
  • Organizer: 19th European Meeting on Hypertension
  • Place of Presentation: Milan, Italy
  • Year and Date: 2009-06-13
• [Presentation] Chronic treatment with Erythropoietin inhibits oxidative stress and inflammatory reaction in diabetic rat aorta beyond hematopoiesis. (2009)
  • Author(s): Hiroe Toba, Mamiko Yoshida, Kohei Nakashima, Masayuki Morishita, Shoko Murata, Chisato Tojo, Yuko Oshima, Yosuke Morita, Miyuki Kobara, Tetsuo Nakata.
  • Organizer: 19th European Meeting on Hypertension
  • Place of Presentation: Milan, Italy
  • Year and Date: 2009-06-13
• [Presentation] Pitavastatin inhibited diabetic nephropathy and decreased renal renin-angiotensin-aldosterone system in rats (2009)
  • Author(s): Hiroe Toba, Nobuyoshi Imai, Ryoko Serizawa, Tamotsu Takahashi, Takuya Mitani, Miyuki Kobara, Tetsuo Nakata
  • Organizer: 19^<th> European Meeting on Hypertension
  • Place of Presentation: Milan, Italy
  • Year and Date: 2009-06-13
• [Presentation] Chronic treatment with Erythropoietin inhibits oxidative stress and inflammatory reaction in diabetic rat aorta beyond hematopoiesis (2009)
  • Author(s): Hiroe Toba, Mamiko Yoshida, Kohei Nakashima, Masayuki Morishita, Shoko Murata, Chisato Tojo, Yuko Oshima, Yosuke Morita, Miyuki Kobara, Tetsuo Nakata
  • Organizer: 19^<th> European Meeting on Hypertension
  • Place of Presentation: Milan, Italy
  • Year and Date: 2009-06-13
• [Presentation] Erythropoietin attenuates diabetic nephropathy beyond hematopoiesis in streptozotocin-induced diabetic rats. (2008)
  • Author(s): Hiroe Toba, Naoki Sawai, Yosuke Morita, Kohei Nakashima, Mamiko Yoshida, Masayuki Morishita, Miyuki Kobara, Tetsuo Nakata.
  • Organizer: Hypertension2008
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-06-19
• [Presentation] Erythropoietin attenuates diabetic nephropathy beyond hematopoiesis in streptozotocin-induced diabetic rats (2008)
  • Author(s): Hiiroe T, et.al.
  • Organizer: Hypertension2008
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-06-19
• [Presentation] Spironolactone attenuated renal and vascular dysfunction via antioxidant properties and inhibited renal expression of ACE and CYP11B2 in deoxycorticosterone-salt rats. (2008)
  • Author(s): Hiroe Toba, Masafumi Murakami, Takuya Mitani, Nobuyoshi Imai, Ryoko Serizawa, Miyuki Kobara, Tetsuo Nakata.
  • Organizer: Hypertension
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-06-16
• [Presentation] Spironolactone attenuated renal and vascular dysfunction via antioxidant properties and inhibited renal expression of ACE and CYP11B2 in deoxycorticosterone-salt rats (2008)
  • Author(s): Hiiroe T, et.al.
  • Organizer: Hypertension2008
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-06-16