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Development of PEGylated thiol modified protein drugs for the treatment of sepsis

Research Project

Project/Area Number 20790402
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied pharmacology
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

KATSUMI Hidemasa  Kyoto Pharmaceutical University, 薬学部, 助教 (30434666)

Research Collaborator YAMAMOTO Akira  京都薬科大学, 薬学部, 教授 (00166779)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsドラッグデリバリー / 薬学 / 薬物送達システム / 一酸化窒素 / 敗血症 / 活性酸素種 / 血清アルブミン / 活性酸素消去酵素 / 高分子 / polyethylene glycol / 牛血清アルブミン
Research Abstract

To prevent septic shock and hepatitis, prolonged delivery of reduced thiols to the blood circulation was performed in animals by a bolus intravenous injection of polyethylene glycol (PEG)-conjugated thiols modified serum albumin (PEG-BSA-SH). PEG-BSA-SH exhibited a prolonged retention in the plasma after intravenous injection into mice. PEG-BSA-SH also effectively suppressed the septic shock and hepatitis in the sepsis mouse or rat model. These findings indicate that PEG-BSA-SH is a promising compound for the treatment of septic shock and hepatitis.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009 2008

All Presentation (5 results)

  • [Presentation] 抗酸化療法を目指した新規高分子ポリチオールの開発と反応機構の評価2010

    • Author(s)
      長嶋賢太、吉川豊、岡本陽香、勝見英正、山本昌、安井裕之
    • Organizer
      日本薬学会第1 3 0年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗酸化療法を目指した新規高分子ポリチオールの開発と反応機構の評価2010

    • Author(s)
      長嶋賢太、吉川豊、岡本陽香、勝見英正、山本昌、安井裕之
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 還元型高分子チオールによる劇症肝炎抑制機構の解明2009

    • Author(s)
      勝見英正、西山和志、岡本陽香、廣埼力也、坂根稔康、西川元也、山本昌
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 劇症肝炎治療を目的とした新規多価還元型チオールの開発2008

    • Author(s)
      勝見英正、西山和志、岡本陽香、水口寛規、廣崎力也、水山朋美、西川元也、山本昌
    • Organizer
      第61回日本酸化ストレス学会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-20
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 劇症肝炎治療を目的とした新規還元型高分子チオールの開発2008

    • Author(s)
      西山和志、勝見英正、水口寛規、岡本陽香、西川元也、山本昌
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌
    • Year and Date
      2008-05-20
    • Related Report
      2009 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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