Pharmacogenetic research of individual differences in the occurrence of Paroxetine discontinuation syndrome.

• Project/Area Number: 20790405
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Fukuoka University
• Principal Investigator: MURATA Yusuke Fukuoka University, 薬学部, 助教 (90461508)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 選択的セロトニン再取込阻害薬 / パロキセチン / 大うつ病性障害 / 離脱症状 / 薬理遺伝学

Research Abstract

Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has now become the first-line treatment for depression and anxiety disorder. However, discontinuation syndrome following abrupt withdrawal or dose reduction of SSRIs has been recently documented. There are no studies with regard to assess the relation of SSRI discontinuation syndrome and gene polymorphisms. In this study, we investigated the effect of the serotonin-related genetic polymorphisms on the occurrence of paroxetine discontinuation syndrome. In conclusion, the abrupt stoppage of medication is a major risk factor for the occurrence of paroxetine discontinuation syndrome. In addition, the C(-1019)G polymorphism of the 5-HT1A receptor gene may be related to the occurrence of paroxetine discontinuation syndrome.

Research Products

• [Journal Article] Effects of the serotonin 1A, 2A, 2C, 3A, and 3B and serotonin transporter gene polymorphisms on the occurrence of paroxetine discontinuation syndrome. (2010)
  • Author(s): Murata Y, Kobayashi D, Imuta N, Haraguchi K, Ieiri I, Nishimura R, Koyama S, Mine K.
  • Journal Title: J Clin Psychopharmacol. 30(1) Pages: 11-17
  • Peer Reviewed
• [Journal Article] Effects of the serotonin 1A, 2A, 2C, 3A, and 3B and serotonin transporter gene polymorphisms on the occurrence of paroxetine discontinuation syndrome (2010)
  • Author(s): Murata Y, Kobayashi D, Imuta N, Haraguchi K, Ieiri I, Nishimura R, Koyama S, Mine K.
  • Journal Title: Journal of Clinical Psychopharmacology 1 Pages: 11-17
  • Peer Reviewed
• [Presentation] ゆっくりとした減量によりパロキセチンの離脱症状発現を予防できるか? (2008)
  • Author(s): 村田雄介
  • Organizer: 第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京・品川プリンスホテル
  • Year and Date: 2008-10-03