| Project/Area Number |
20790406
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Tokyo Metropolitan Organization for Medical Research |
|---|
Principal Investigator |
KASAI Shinya Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 研究員 (20399471)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 遺伝子多型 / 個人差 / 鎮痛薬感受性 / プロオピオメラノコルチン遺伝子 / 鎮痛薬 / 依存性 / 感受性個人差 / プロオピオメラノコルチン / 発現制御 |
|---|
| Research Abstract |
In the previous study, a single nucleotide polymorphism (SNP) in the proopiomelanocortin (POMC) gene was identified to be associated with individual differences in opioid analgesia and susceptibility to alcohol dependence. The POMC SNP dose not form linkage disequilibrium block with other polymorphisms, suggesting that the SNP would directly affect on individual differences in analgesia and susceptibility to dependence. The expression vector was constructed with 5' flanking region of the POMC gene including the SNP. The human POMC gene consists of three exons, but effective polymorphisms for allelic imbalance experience (AIE) were identified in the last exon. The expression analyses are now on going, and molecular mechanisms underlying individual differences in opioid sensitivity or susceptibility to dependence would be elucidated by these analyses.
|
