| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We reported the possibility that the immunocomplex consisting of bacterial 17-kDa protein, platelet and anti-H. pylori antibodies were involved in development of H. pylori-associated chronic idiopathic thrombocytopenic purpura (cITP). The H. pylori outer membrane protein (OMP) was identified among 11 candidates as one of bacterial factors involved in development of H. pylori - associated cITP. The recombinant fusion protein (rOMP) prepared was immunized with a rabbit to obtain polyclonal antibody. The specificity of the antibody was confirmed and this antibody could detect the OMP among individual H. pylori strains. The OMP was identified as one of the 17-kDa proteins of H. pylori, which binds to platelet, leading to aggregation.
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