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Establishment of new pathological analysis by imaging mass spectrometry

Research Project

Project/Area Number 20790419
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Laboratory medicine
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

ZAIMA Nobuhiro  Hamamatsu University School of Medicine, 分子イメージング先端研究センター, 特任助教 (40455572)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords質量顕微鏡法 / 病理解析 / 脂質代謝異常 / 質量顕微鏡 / 脂質 / 脂質蓄積ミオパチー / 脂肪肝
Research Abstract

Biochemical approaches, such as staining, are widely used as pathological analysis. These methods are essential for pathological analysis. However, they have some disadvantages. For example, they cannot be applied to non-targeting analysis. Establishment of new pathological method is important to analyze idiopathic disease. In this study, new pathological analysis using imaging mass spectrometry for non-targeting analysis was established.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Principal component analysis of direct matrix-assisted laser desorption/ionization mass spectrometric data related to metabolites of fatty liver2009

    • Author(s)
      Zaima N, Matsuyama Y, Setou M
    • Journal Title

      J Oleo Sci 58

      Pages: 267-273

    • NAID

      130000106453

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of metabolites by MALDI mass spectrometry2009

    • Author(s)
      Zaima N, Hayasaka T, Goto-Inoue N, Setou M
    • Journal Title

      J Oleo Sci 58

      Pages: 415-419

    • NAID

      130000126093

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of metabolites by MALDI mass spectrometry2009

    • Author(s)
      Nobuhiro Zaima
    • Journal Title

      Journal of Oleo Science 58

      Pages: 415-419

    • NAID

      130000126093

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Principal component analysis of direct matrix-assisted laser desorption/ionization mass spectrometric data related to metabolites of fatty liver2009

    • Author(s)
      Nobuhiro Zaima
    • Journal Title

      Journal of Oleo Science (In press)

    • NAID

      130000106453

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The abnormal accumulation of metabolites in neutral lipid storage myopathy caused by adipose triacylglycerol lipase mutation.2009

    • Author(s)
      Zaima, N., Sugiura, Y., Hirano, K., Ohkuma, A., Okahashi, S., Noguchi, S., Nishino, I., Ibi, T., Sahashi, K., Setou, M.
    • Organizer
      The American Oil Chemists' Society
    • Place of Presentation
      USA
    • Year and Date
      2009-05-04
    • Related Report
      2009 Final Research Report
  • [Presentation] The pathological analysis of neutral lipid storage myopathy caused by a dipose triacylglycerol lipase mutation.2009

    • Author(s)
      Nobuhiro Zaima
    • Organizer
      The American Oil Chemists' Society
    • Place of Presentation
      Florida (USA)
    • Year and Date
      2009-05-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of Lipid Storage Myopathy (ETFDH mutant or PNPLA2 mutant) by Direct Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry2008

    • Author(s)
      Nobuhiro Zaima
    • Organizer
      American Society for Mass Spectrometry
    • Place of Presentation
      Denver (USA)
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of Lipid Storage Myopathy (ETFDH mutant or PNPLA2 mutant) by Direct Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry2008

    • Author(s)
      Zaima, N., Sugiura, Y., Ohkuma, A., Okahashi, S., Noguchi, S., Nishino, I., Ibi, Tohru., Ozawa, F., Sahashi, K., Setou M.
    • Organizer
      Conference Proceedings, 56th ASMS Conference on Mass Spectrometry
    • Place of Presentation
      USA
    • Year and Date
      2008-05-06
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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